Exposure to the metalloid arsenic is a daily occurrence because of its environmental
pervasiveness. Arsenic, which is found in several different chemical forms and oxidation …

Chemical carcinogenesis follows a multistep process involving both mutation and increased
cell proliferation. Oxidative stress can occur through overproduction of reactive oxygen and …

Carcinoma-associated fibroblasts (CAF) mediate the onset of a proinvasive tumour
microenvironment. The proinflammatory cytokine LIF reprograms fibroblasts into a …

Although there have been many molecular studies of morphological mutants generated in
the laboratory, it is unclear how these are related to mutants in natural populations, where …

Background: It is widely accepted that the adenoma–carcinoma sequence represents the
process by which most, if not all, colorectal cancers arise. The evidence supporting this …

Epidemiological data have identified chronic alcohol consumption as a significant risk factor
for upper alimentary tract cancer, including cancer of the oropharynx, larynx and the …

DNA–(cytosine-5) methyltransferase (MCMT) methylates newly replicated mammalian DNA,
but the factors regulating this activity are unknown. Here, MCMT is shown to bind …

Mechanisms of Chemical Carcinogenicity and Mutagenicity: A Review with Implications for
Predictive Toxicology | Chemical Reviews ACS ACS Publications C&EN CAS Find my …

The anti-skin carcinogenic effects of green tea catechins have been studied extensively in
vitro and in vivo models but the precise epigenetic molecular mechanisms are still unclear …

Inorganic arsenic, a human carcinogen, is enzymatically methylated for detoxication,
consuming S-adenosyl-methionine (SAM) in the process. The fact that DNA …