Age-associated changes to the mammalian DNA methylome are well documented and
thought to promote diseases of aging, such as cancer. Recent studies have identified …

Researchers view vast zeros in single-cell RNA-seq data differently: some regard zeros as
biological signals representing no or low gene expression, while others regard zeros as …

Understanding the diversity of human tissues is fundamental to disease and requires linking
genetic information, which is identical in most of an individual's cells, with epigenetic …

DNA methylation is among the best studied epigenetic modifications and is essential to
mammalian development. Although the methylation status of most CpG dinucleotides in the …

Large-scale chromosome structure and spatial nuclear arrangement have been linked to
control of gene expression and DNA replication and repair. Genomic techniques based on …

DNA methylation is an important epigenetic mechanism that regulates gene expression. To
date, most DNA methylation studies have focussed on CpG islands in the gene promoter …

As studies of DNA methylation increase in scope, it has become evident that methylation has
a complex relationship with gene expression, plays an important role in defining cell types …

Although the function of DNA methylation in gene promoter regions is well established in
transcriptional repression, the function of the evolutionarily conserved widespread …

We have extensively characterized the DNA methylomes of 139 patients with chronic
lymphocytic leukemia (CLL) with mutated or unmutated IGHV and of several mature B-cell …

Background Dynamic changes to the epigenome play a critical role in establishing and
maintaining cellular phenotype during differentiation, but little is known about the normal …