High impulsive and aggressive traits associate with poor behavioural self-control. Despite
their importance in predicting behavioural negative outcomes including suicide, the …

Background Aberrant DNA methylation is a hallmark of many cancers. Classically there are
two types of endometrial cancer, endometrioid adenocarcinoma (EAC), or Type I, and …

Background: Glycosylation is one of the most fundamental post-translational modifications.
Importantly, glycosylation is altered in many cancers. These alterations have been proven to …

Alterations in DNA methylation have been reported to occur during development and aging;
however, much remains to be learned regarding post-natal and age-associated epigenome …

DNA methylation is an important mechanism by which gene transcription and hence cellular
function are regulated. Here, we provide detailed functional genome-wide methylome maps …

β cell dysfunction is central to the development and progression of type 2 diabetes (T2D).
T2D develops when β cells are not able to compensate for the increasing demand for insulin …

DNA methylation at the promoter of a gene is presumed to render it silent, yet a sizable
fraction of genes with methylated proximal promoters exhibit elevated expression. Here, we …

Complex developmental processes such as hematopoiesis require a series of precise and
coordinated changes in cellular identity to ensure blood homeostasis. Epigenetic …

Many differentially methylated genes have been identified in prostate cancer (PCa),
primarily using candidate gene-based assays. Recently, several global DNA methylation …

Histone H3 lysine 4 trimethylation (H3K4me3) is often stated as a mark of transcriptionally
active promoters. However, closer study of the positioning of H3K4me3 shows the mark …