With the development of human society, haze has become an important form of air pollution.
Haze is a mixture of fog and haze, and the main component of haze is fine particulate matter …

Chromatin structure is intimately connected with gene expression and cell identity. Here we
review recent advances in the field and discuss how establishment of cell identity during …

Technological advances have enabled the profiling of multiple molecular layers at single-
cell resolution, assaying cells from multiple samples or conditions. Consequently, there is a …

DNA methylation is important for the epigenetic regulation of gene expression and plays a
critical role in mammalian development. However, the dynamic regulation of genome-wide …

The vertebrate body plan and organs are shaped during a conserved embryonic phase
called the phylotypic stage. However, the mechanisms that guide the epigenome through …

The awakening of the genome after fertilization is a cornerstone of animal development.
However, the mechanisms that activate the silent genome after fertilization are poorly …

Background Uncovering mechanisms of epigenome evolution is an essential step towards
understanding the evolution of different cellular phenotypes. While studies have confirmed …

The spermatozoa and oocyte are very specialized cells which possess the unique ability to
fuse and to produce an embryo. This embryo will develop into a mature organism capable of …

Developing and adult tissues use different cis-regulatory elements. Although DNA at some
decommissioned embryonic enhancers is hypomethylated in adult cells, it is unknown …

Parental experience with parasites and pathogens can lead to increased offspring
resistance to infection, through a process known as transgenerational immune priming …