Studies have reported a positive correlation between elevated CD8+ T cells in the tumor
microenvironment (TME) and good prognosis in cancer. However, the mechanisms linking T …

The identification of heterozygous neomorphic isocitrate dehydrogenase (IDH) mutations
across multiple cancer types including both solid and hematologic malignancies has …

Compelling evidence have demonstrated that bulk tumors can arise from a unique subset of
cells commonly termed “cancer stem cells” that has been proposed to be a strong driving …

Advances in cancer research in the past have led to an evolving understanding of cancer
pathogenesis and the development of novel drugs that significantly improve patient …

Cervical cancer (CC) is the fourth most common type of gynecological malignancy affecting
females worldwide. Most CC cases are linked to infection with high-risk human …

Background Decitabine is widely used in the treatment of acute myeloid leukemia (AML) in
elderly patients. Low-dose Vitamin C has also been indicated to induce DNA demethylation …

Breast cancer (BC) is the most prevalent cancer in women worldwide. Although extensive
studies are ongoing concerning its intricate molecular mechanisms, development of novel …

Pancreatic ductal adenocarcinoma (PDAC) and other carcinomas are hierarchically
organized, with cancer stem cells (CSC) residing at the top of the hierarchy, where they drive …

Aza-2'-deoxycytidine (AzaD), also known as Decitabine, is a deoxycytidine analog that is
typically used to activate methylated and silenced genes by promoter demethylation …

Prostate cancer (PCa) is the most frequently diagnosed cancer in men and the second most
common cause of cancer-related mortality among men in the developed world …