Background Esophageal squamous cell cancer (ESCC) is one kind of frequent digestive
tumor. The inflammatory environment plays an important role in the tumorigenesis and …

Testicular germ cell tumors (TGCTs) share germline ancestry but diverge phenotypically and
clinically as seminoma (SE) and nonseminoma (NSE), the latter including the pluripotent …

Opinion statement: The cells of malignant cancers result in the evolution of cells with stem-
like characteristics, commonly known as cancer stem cells (CSCs). Progress of anticancer …

Abdominal aortic aneurysm (AAA) is characterised by the chronic degradation and gradual,
irreversible dilation of the abdominal aorta. Smoking, genetics, male sex and increased age …

Glioblastoma multiforme (GBM), designated as World Health Organization (WHO) grade IV
astrocytoma, is a lethal and therapy-resistant brain cancer comprised of several tumor cell …

Background: High attrition rates in drug discovery call for new approaches to improve target
validation. Academia is filling gaps, but often lacks the experience and resources of the …

In testicular germ cell tumor type II (TGCT), a seminoma subtype expresses an induced
pluripotent stem cell (iPSC) panel with four upregulated genes, OCT4/POU5F1, SOX17 …

Pancreatic cancer is one of the most aggressive human cancer types with a five-year
survival less than 7%. Emerging evidence revealed that many genetic alterations in …

Pediatric neuroblastomas (NBs) are heterogeneous, aggressive, therapy-resistant
embryonal tumours that originate from cells of neural crest (NC) origin and in particular …

Background Cancer stem cells (CSCs), in choriocarcinoma and other carcinomas, possess
the ability of self-renewal and multilineage differentiation potential. We previous isolated …