The DNA methyltransferase (DNMT) inhibitor 5-azacytidine (5-aza) causes genomic
demethylation to regulate gene expression. However, it remains unclear whether 5-aza …

Background C-kit-positive cardiac stem cells (CSCs) have been shown to be a promising
candidate treatment for myocardial infarction and heart failure. Insulin-like growth factor …

Tumor immunity is a promising topic in the area of cancer therapy. The 'soil'function of the
tumor microenvironment (TME) for tumor growth has attracted wide attention from scientists …

Diffuse large B-cell lymphoma (DLBCL) is the most common form of lymphoma and shows
considerable clinical and biological heterogeneity. Much research is currently focused on …

As a class, epigenetic enzymes have been identified as clear targets for cancer therapeutics
based on their broad hyperactivity in solid and hematological malignancies. The search for …

Prostate cancer is the second leading cause of cancer death among men in the United
States. Depending upon the histopathological subtypes of prostate cancers, various …

Defects in development of the secondary palate, which arise from the embryonic first
branchial arch (1-BA), can cause cleft palate (CP). Administration of 5-Aza-2 …

Introduction and aim. Epigenetic alterations play an essential role in cancer onset and
progression, thus studies of drugs targeting the epigenetic machinery are a principal …

Advanced grades of glioblastoma are highly aggressive, especially in terms of multisite
spread within the brain or even to distant sites at the spinal cord. In advanced grades of …

Cancer stem cell (CSC) derive from normal adult mutated stem cell, which are a small sub-
population of cells within tumors, having self-renewal capacity, pluripotency as well as tumor …