Epigenetics is dynamic and heritable modifications to the genome that occur independently
of DNA sequence. It requires interactions cohesively with various enzymes and other …

Chromatin, the template for epigenetic regulation, is a highly dynamic entity that is constantly
reshaped during early development and differentiation. Epigenetic modification of chromatin …

Retrotransposons have generated about 40% of the human genome. This review examines
the strategies the cell has evolved to coexist with these genomic “parasites”, focussing on …

DNA methylation is among the best studied epigenetic modifications and is essential to
mammalian development. Although the methylation status of most CpG dinucleotides in the …

DNA methylation loss occurs frequently in cancer genomes, primarily within lamina-
associated, late-replicating regions termed partially methylated domains (PMDs). We …

DNA methylation is an epigenetic mechanism that is essential for regulating gene
transcription. However, aberrant DNA methylation, which is a nearly universal finding in …

The term epigenetics was first used to refer to the complex interactions between the genome
and the environment that are involved in development and differentiation in higher …

A DNA sequence is the hard copy of the human genome and it is a driving force in
determining the physiological processes in an organism. Concurrently, the chemical …

The widely-cited model of maintenance of DNA methylation at CpG sites implies that DNA
methylation is introduced by the Dnmt3 de novo DNA methyltransferases during early …

DNA methylation is an epigenetic mark that is erased in the early embryo and then re-
established at the time of implantation. In this Review, dynamics of DNA methylation during …