Our current view of DNA methylation processes is strongly moving: First, even if it was
generally admitted that DNMT3A and DNMT3B are associated with de novo methylation and …

Patterns of DNA methylation and chromatin structure are profoundly altered in neoplasia
and include genome-wide losses of, and regional gains in, DNA methylation. The recent …

Dnmt1 and Dnmt3a are important DNA methyltransferases that are expressed in postmitotic
neurons, but their function in the CNS is unclear. We generated conditional mutant mice that …

DNA methylation plays an important role in epigenetic signalling, having an impact on gene
regulation, chromatin structure, development and disease. Here, we review the structures …

DNA methylation patterns are set up early in mammalian development and are then copied
during the division of somatic cells. A long-established model for the maintenance of these …

The developmental programme of embryogenesis is controlled by both genetic and
epigenetic mechanisms. An emerging theme from recent studies is that the regulation of …

The past few years have seen an explosion of interest in the epigenetics of cancer. This has
been a consequence of both the exciting coalescence of the chromatin and DNA …

Epigenetic modifications are crucial for the identity and stability of cells, and, when aberrant,
can lead to disease. During mouse development, the genome-wide epigenetic states of pre …

The enzymatic control of the setting and maintenance of symmetric and non-symmetric DNA
methylation patterns in a particular genome context is not well understood. Here, we …

A complex interplay between multiple biological effects shapes the aging process. The
advent of genome-wide quantitative approaches in the epigenetic field has highlighted the …