The role of hypoxia-inducible factors in cardiovascular diseases
B Yu, X Wang, Y Song, G Xie, S Jiao, L Shi… - Pharmacology & …, 2022 - Elsevier
Cardiovascular diseases are the leading cause of death worldwide. During the development
of cardiovascular diseases, hypoxia plays a crucial role. Hypoxia-inducible factors (HIFs) are …
of cardiovascular diseases, hypoxia plays a crucial role. Hypoxia-inducible factors (HIFs) are …
Pharmacologic management of aneurysms
JH Lindeman, JS Matsumura - Circulation research, 2019 - Am Heart Assoc
Current management of aortic aneurysms relies exclusively on prophylactic operative repair
of larger aneurysms. Great potential exists for successful medical therapy that halts or …
of larger aneurysms. Great potential exists for successful medical therapy that halts or …
H19 induces abdominal aortic aneurysm development and progression
Background: Long noncoding RNAs have emerged as critical molecular regulators in
various biological processes and diseases. Here we sought to identify and functionally …
various biological processes and diseases. Here we sought to identify and functionally …
[HTML][HTML] Macrophage metabolic reprogramming aggravates aortic dissection through the HIF1α-ADAM17 pathway✰
G Lian, X Li, L Zhang, Y Zhang, L Sun, X Zhang… - …, 2019 - thelancet.com
Background Aortic dissection is a severe inflammatory vascular disease with high mortality
and limited therapeutic options. The hallmarks of aortic dissection comprise aortic …
and limited therapeutic options. The hallmarks of aortic dissection comprise aortic …
[HTML][HTML] Hypoxia inducible factor 1α in vascular smooth muscle cells promotes angiotensin II-induced vascular remodeling via activation of CCL7-mediated …
D Qi, M Wei, S Jiao, Y Song, X Wang, G Xie… - Cell death & …, 2019 - nature.com
The process of vascular remodeling is associated with increased hypoxia. However, the
contribution of hypoxia-inducible factor 1α (HIF1α), the key transcription factor mediating …
contribution of hypoxia-inducible factor 1α (HIF1α), the key transcription factor mediating …
Inhibition of VEGF (vascular endothelial growth factor)-A or its receptor activity suppresses experimental aneurysm progression in the aortic elastase infusion model
Objective: We examined the pathogenic significance of VEGF (vascular endothelial growth
factor)-A in experimental abdominal aortic aneurysms (AAAs) and the translational value of …
factor)-A in experimental abdominal aortic aneurysms (AAAs) and the translational value of …
[HTML][HTML] Hypoxia-inducible factor 1 in clinical and experimental aortic aneurysm disease
Objective Mural angiogenesis and macrophage accumulation are two pathologic hallmarks
of abdominal aortic aneurysm (AAA) disease. The heterodimeric transcription factor hypoxia …
of abdominal aortic aneurysm (AAA) disease. The heterodimeric transcription factor hypoxia …
[HTML][HTML] Chronic kidney disease induces a systemic microangiopathy, tissue hypoxia and dysfunctional angiogenesis
HU Prommer, J Maurer, K Von Websky, C Freise… - Scientific reports, 2018 - nature.com
Chronic kidney disease (CKD) is associated with excessive mortality from cardiovascular
disease (CVD). Endothelial dysfunction, an early manifestation of CVD, is consistently …
disease (CVD). Endothelial dysfunction, an early manifestation of CVD, is consistently …
[HTML][HTML] Angiotensin-converting enzyme 2, coronavirus disease 2019, and abdominal aortic aneurysms
Objective Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the etiologic
agent of the current, world-wide coronavirus disease 2019 (COVID-19) pandemic …
agent of the current, world-wide coronavirus disease 2019 (COVID-19) pandemic …
[HTML][HTML] Treatment with the prolyl hydroxylase inhibitor JNJ promotes abdominal aortic aneurysm progression in diabetic mice
Objective Prolyl hydroxylase domain containing proteins (PHD) rigorously regulate
intracellular hypoxia inducible factor-1 (HIF-1) protein expression and activity. Diabetes …
intracellular hypoxia inducible factor-1 (HIF-1) protein expression and activity. Diabetes …