Cardiovascular diseases are the leading cause of death worldwide. During the development
of cardiovascular diseases, hypoxia plays a crucial role. Hypoxia-inducible factors (HIFs) are …

Current management of aortic aneurysms relies exclusively on prophylactic operative repair
of larger aneurysms. Great potential exists for successful medical therapy that halts or …

Background: Long noncoding RNAs have emerged as critical molecular regulators in
various biological processes and diseases. Here we sought to identify and functionally …

Background Aortic dissection is a severe inflammatory vascular disease with high mortality
and limited therapeutic options. The hallmarks of aortic dissection comprise aortic …

The process of vascular remodeling is associated with increased hypoxia. However, the
contribution of hypoxia-inducible factor 1α (HIF1α), the key transcription factor mediating …

Objective: We examined the pathogenic significance of VEGF (vascular endothelial growth
factor)-A in experimental abdominal aortic aneurysms (AAAs) and the translational value of …

Objective Mural angiogenesis and macrophage accumulation are two pathologic hallmarks
of abdominal aortic aneurysm (AAA) disease. The heterodimeric transcription factor hypoxia …

Chronic kidney disease (CKD) is associated with excessive mortality from cardiovascular
disease (CVD). Endothelial dysfunction, an early manifestation of CVD, is consistently …

Objective Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the etiologic
agent of the current, world-wide coronavirus disease 2019 (COVID-19) pandemic …

Objective Prolyl hydroxylase domain containing proteins (PHD) rigorously regulate
intracellular hypoxia inducible factor-1 (HIF-1) protein expression and activity. Diabetes …