The packaging of DNA into chromatin in eukaryotes regulates gene transcription, DNA
replication and DNA repair. ATP-dependent chromatin remodelling enzymes (re) arrange …

Eukaryotic DNA-binding proteins operate in the context of chromatin, where nucleosomes
are the elementary building blocks. Nucleosomal DNA is wrapped around a histone core …

Eukaryotic genomes are organized into chromatin domains. The molecular mechanisms
driving the formation of these domains are difficult to dissect in vivo and remain poorly …

Unlike other chromatin remodelers, INO80 preferentially mobilizes hexasomes, which can
form during transcription. Why INO80 prefers hexasomes over nucleosomes remains …

Nearly all essential nuclear processes act on DNA packaged into arrays of nucleosomes.
However, our understanding of how these processes (for example, DNA replication, RNA …

The origin recognition complex (ORC) is essential for initiation of eukaryotic chromosome
replication as it loads the replicative helicase—the minichromosome maintenance (MCM) …

The nucleosomal landscape of chromatin depends on the concerted action of chromatin
remodelers. The INO80 remodeler specifically places nucleosomes at the boundary of gene …

The fundamental molecular determinants by which ATP-dependent chromatin remodelers
organize nucleosomes across eukaryotic genomes remain largely elusive. Here, chromatin …

Loss of H2A–H2B histone dimers is a hallmark of actively transcribed genes, but how the
cellular machinery functions in the context of noncanonical nucleosomal particles remains …

Summary Nucleosome-displacing-factors (NDFs) in yeast, similar to pioneer factors in
higher eukaryotes, can open closed chromatin and generate nucleosome-depleted regions …