Cryptococcus neoformans and Cryptococcus gattii, the etiologic agents of cryptococcosis

KJ Kwon-Chung, JA Fraser… - Cold Spring …, 2014 - perspectivesinmedicine.cshlp.org
Cryptococcus neoformans and Cryptococcus gattii are the two etiologic agents of
cryptococcosis. They belong to the phylum Basidiomycota and can be readily distinguished …

Basic principles of the virulence of Cryptococcus

O Zaragoza - Virulence, 2019 - Taylor & Francis
Among fungal pathogens, Cryptococcus neoformans has gained great importance among
the scientific community of several reasons. This fungus is the causative agent of …

Metals in fungal virulence

F Gerwien, V Skrahina, L Kasper… - FEMS microbiology …, 2018 - academic.oup.com
Metals are essential for life, and they play a central role in the struggle between infecting
microbes and their hosts. In fact, an important aspect of microbial pathogenesis is the …

[HTML][HTML] Cryptococcus neoformans adapts to the host environment through TOR-mediated remodeling of phospholipid asymmetry

LC Ristow, AJ Jezewski, BJ Chadwick… - Nature …, 2023 - nature.com
Cryptococcus spp. are environmental fungi that first must adapt to the host environment
before they can cause life-threatening meningitis in immunocompromised patients. Host …

[HTML][HTML] Chitin recognition via chitotriosidase promotes pathologic type-2 helper T cell responses to cryptococcal infection

DL Wiesner, CA Specht, CK Lee, KD Smith… - PLoS …, 2015 - journals.plos.org
Pulmonary mycoses are often associated with type-2 helper T (Th2) cell responses.
However, mechanisms of Th2 cell accumulation are multifactorial and incompletely known …

Cryptococcus neoformans: historical curiosity to modern pathogen

D Srikanta, FH Santiago‐Tirado, TL Doering - Yeast, 2014 - Wiley Online Library
The importance of the Basidiomycete Cryptococcus neoformans to human health has
stimulated its development as an experimental model for both basic physiology and …

[HTML][HTML] The pH-Responsive PacC Transcription Factor of Aspergillus fumigatus Governs Epithelial Entry and Tissue Invasion during Pulmonary Aspergillosis

M Bertuzzi, M Schrettl, L Alcazar-Fuoli, TC Cairns… - PLoS …, 2014 - journals.plos.org
Destruction of the pulmonary epithelium is a major feature of lung diseases caused by the
mould pathogen Aspergillus fumigatus. Although it is widely postulated that tissue invasion …

[HTML][HTML] Cryptococcal pathogenic mechanisms: a dangerous trip from the environment to the brain

SK Esher, O Zaragoza, JA Alspaugh - Memorias do Instituto Oswaldo …, 2018 - SciELO Brasil
Cryptococcus neoformans is an opportunistic pathogenic yeast that causes serious
infections, most commonly of the central nervous system (CNS). C. neoformans is mainly …

Virulence mechanisms and Cryptococcus neoformans pathogenesis

JA Alspaugh - Fungal Genetics and Biology, 2015 - Elsevier
The human fungal pathogen Cryptococcus neoformans is able to rapidly and effectively
adapt to varying conditions, favoring its survival in the environment and in the infected host …

Gene expression of diverse Cryptococcus isolates during infection of the human central nervous system

CH Yu, P Sephton-Clark, JL Tenor, DL Toffaletti… - Mbio, 2021 - Am Soc Microbiol
Cryptococcus neoformans is a major human central nervous system (CNS) fungal pathogen
causing considerable morbidity and mortality. In this study, we provide the widest view to …