The outer retina is nourished from the choroid, a capillary bed just inside the sclera. O2,
glucose, and other nutrients diffuse out of the choroid and then filter through a monolayer of …

Blood vessels have long been considered as passive conduits for delivering blood.
However, in recent years, cells of the vessel wall (endothelial cells, smooth muscle cells and …

Rationale: Pericytes are capillary mural cells playing a role in stabilizing newly formed blood
vessels during development and tissue repair. Loss of pericytes has been described in …

NADH provides electrons for aerobic ATP production. In cells deprived of oxygen or with
impaired electron transport chain activity, NADH accumulation can be toxic. To minimize …

Recent advancements in single-cell RNA sequencing (scRNA-seq) have facilitated the
classification of thousands of cells through transcriptome profiling, wherein accurate cell …

Background. This study is aimed at investigating the changes in relevant pathways and the
differential expression of related gene expression after ischemic stroke (IS) at the single‐cell …

Many patients with diabetic eye disease respond inadequately to anti-VEGF therapies,
implicating additional vasoactive mediators in its pathogenesis. We demonstrate that levels …

Hair cells, the mechanosensory receptors of the inner ear, are responsible for hearing and
balance. Hair cell death and consequent hearing loss are common results of treatment with …

Glaucoma and other optic neuropathies affect millions of people worldwide, ultimately
causing progressive and irreversible degeneration of retinal ganglion cells (RGCs) and …

The ability to quantify DNA, RNA, and protein variations at the single cell level has
revolutionized our understanding of cellular heterogeneity within tissues. Via such analyses …