DNA demethylation can occur passively by “dilution” of methylation marks by DNA
replication, or actively and independently of DNA replication. Direct conversion of 5 …

Research over the years has shown that causes of Alzheimer's disease are not well
understood, but over the past years, the involvement of epigenetic mechanisms in the …

While the field of epigenetics is increasingly recognized to contribute to the emergence of
phenotypes in mammalian research models across different developmental and …

Oxidative genome damage is an unavoidable consequence of cellular metabolism. It arises
at gene regulatory elements by epigenetic demethylation during transcriptional activation …

During embryo development, DNA methylation is established by DNMT3A/3B and
subsequently maintained by DNMT1. While much research has been done in this field, the …

Abstract LSH, a SNF2 family DNA helicase, is a key regulator of DNA methylation in
mammals. How LSH facilitates DNA methylation is not well defined. While previous studies …

Faithful inheritance of DNA methylation across cell division requires DNMT1 and its
accessory factor UHRF1. However, how this axis is regulated to ensure DNA methylation …

Early detection and characterization of molecular events associated with tumorgenesis
remain high priorities. Genome-wide epigenetic assays are promising diagnostic tools, as …

Previous studies have implicated an essential role for UHRF1-mediated histone H3
ubiquitination in recruiting DNMT1 to replication sites for DNA maintenance methylation …

DNA methyltransferases (DNMTs) are widely expressed in the brain, dictating the
transcriptional activity of genes through various epigenetic mechanisms. Functional …