Ever since the discovery of DNA methylation at cytosine residues, the role of this so called
fifth base has been extensively studied and debated. Until recently, the majority of DNA …

Isoflavones (IF) such as genistein are cancer preventive phytochemicals found in soy and
other legumes. Epidemiological studies point to a reduced risk for hormone‑dependent …

We examined whether persistence of epigenetic DNA methylation (DNA-me) alterations at
specific loci over two different time points in people with diabetes are associated with …

Determining the effect of DNA methylation on chromatin structure and function in higher
organisms is challenging due to the extreme complexity of epigenetic regulation. We studied …

Purpose: We utilized whole-genome mapping of promoters that are activated by DNA
hypomethylation in hepatocellular carcinoma (HCC) clinical samples to shortlist novel …

The broad clinical spectrum of neuroblastoma ranges from spontaneous regression to rapid
progression despite intensive multimodal therapy. This diversity is not fully explained by …

DNA hypomethylation was previously implicated in cancer progression and metastasis. The
purpose of this study was to examine whether stilbenoids, resveratrol and pterostilbene …

In recent years, technological advances have enabled a detailed landscaping of the
epigenome and the mechanisms of epigenetic regulation that drive normal cell function …

Previous studies indicate that a subgroup of suicide completers has low cortical brain
expression levels of TrkB-T1, a TrkB gene transcript that is highly expressed in astrocytes …

The transcription factors (TFs) of the HOX family play significant roles during early embryonic
development and cellular processes. They also play a key role in tumorigenesis as tumor …