The success of anticancer therapy is usually limited by the development of drug resistance.
Such acquired resistance is driven, in part, by intratumoural heterogeneity—that is, the …

More and more in-depth studies have revealed that the occurrence and development of
tumors depend on gene mutation and tumor heterogeneity. The most important …

Insufficient tissue oxygenation, or hypoxia, contributes to tumor aggressiveness and has a
profound impact on clinical outcomes in cancer patients. At decreased oxygen tensions …

Hypoxia-inducible factors (HIFs) mediate adaptive physiological responses to hypoxia. In
human cancers that are accessible for O 2 electrode measurements, intratumoral hypoxia is …

The mechanism of epithelial-mesenchymal transition (EMT) consists of the cellular
phenotypic transition from epithelial to mesenchymal status. The cells exhibiting EMT exist in …

Epithelial-mesenchymal transition (EMT) is a cellular biological process involved in
migration of primary cancer cells to secondary sites facilitating metastasis. Besides, EMT …

The essential hallmarks of cancer are intertwined with an altered cancer cell-intrinsic
metabolism, either as a consequence or as a cause. As an example, the resistance of …

Small-molecule stabilizers of hypoxia inducible factor (HIF) are being developed for the
treatment of renal anaemia. These molecules inhibit prolyl hydroxylase domain-containing …

The molecular mechanisms that underlie tumour progression are still poorly understood, but
recently our knowledge of particular aspects of some of these processes has increased …

Tumour cells emerge as a result of genetic alteration of signal circuitries promoting cell
growth and survival, whereas their expansion relies on nutrient supply. Oxygen limitation is …