Inflammation is a physiological process essential for maintaining homeostatic mechanisms
in human, but however, exaggerated inflammatory responses are closely related to many …

Abstract Ischemic/reperfusion (I/R) injury causes a series of serious clinical problems
associated with high morbidity and mortality in various disorders, such as acute kidney injury …

The aberrant activation of complement system in several kidney diseases suggests that this
pillar of innate immunity has a critical role in the pathophysiology of renal damage of …

Epigenetic memory, which refers to the ability of cells to retain and transmit epigenetic marks
to their daughter cells, maintains unique gene expression patterns. Establishing …

Abstract Ischemia/reperfusion (IR) injury, a main reason of mortality and morbidity
worldwide, occurs in many organs and tissues. As a result of IR injury, senescent cells can …

Advanced donor age is a risk factor for poor survival following lung transplantation.
However, recent work identifying epigenetic determinants of aging has shown that biologic …

The biological age of an organ may represent a valuable tool for assessing its quality,
especially in the elder. We examined the biological age of the kidneys [right (RK) and left …

The pathogenesis of systemic lupus erythematosus (SLE) remains elusive to this day;
however, genetic, epigenetic, and environmental factors have been implicated to be …

In order to develop new efficient therapies for organ transplantation, it is essential to acquire
a comprehensive knowledge of the molecular mechanisms and processes, such as immune …

Introduction Kidney transplantation remains the gold standard of treatment for end-stage
renal disease (ESRD), with improved patient outcomes compared with dialysis. Epigenome …