[HTML][HTML] Targeting protein arginine methyltransferase 5 in cancers: Roles, inhibitors and mechanisms
Y Chen, X Shao, X Zhao, Y Ji, X Liu, P Li… - Biomedicine & …, 2021 - Elsevier
The protein arginine methyltransferase 5 (PRMT5) as the major type II arginine
methyltransferase catalyzes the mono-and symmetric dimethylation of arginine residues in …
methyltransferase catalyzes the mono-and symmetric dimethylation of arginine residues in …
Epigenetic regulation of hybrid epithelial-mesenchymal cell states in cancer
RA Sample, MF Nogueira, RD Mitra, SV Puram - Oncogene, 2023 - nature.com
Epithelial-to-mesenchymal transition (EMT) is a process by which cells lose their epithelial
characteristics and gain mesenchymal phenotypes. In cancer, EMT is thought to drive tumor …
characteristics and gain mesenchymal phenotypes. In cancer, EMT is thought to drive tumor …
[HTML][HTML] Gli1 promotes epithelial–mesenchymal transition and metastasis of non-small cell lung carcinoma by regulating snail transcriptional activity and stability
X Lei, Z Li, Y Zhong, S Li, J Chen, Y Ke, S Lv… - … Pharmaceutica Sinica B, 2022 - Elsevier
Metastasis is crucial for the mortality of non-small cell lung carcinoma (NSCLC) patients. The
epithelial–mesenchymal transition (EMT) plays a critical role in regulating tumor metastasis …
epithelial–mesenchymal transition (EMT) plays a critical role in regulating tumor metastasis …
[HTML][HTML] RUNX2 recruits the NuRD (MTA1)/CRL4B complex to promote breast cancer progression and bone metastasis
X Yin, X Teng, T Ma, T Yang, J Zhang, M Huo… - Cell Death & …, 2022 - nature.com
Runt-related transcription factor 2 (RUNX2) is an osteogenesis-related transcription factor
that has emerged as a prominent transcription repressing factor in carcinogenesis. However …
that has emerged as a prominent transcription repressing factor in carcinogenesis. However …
PRMT5 methylating SMAD4 activates TGF-β signaling and promotes colorectal cancer metastasis
A Liu, C Yu, C Qiu, Q Wu, C Huang, X Li, X She, K Wan… - Oncogene, 2023 - nature.com
Perturbations in transforming growth factor-β (TGF-β) signaling can lead to a plethora of
diseases, including cancer. Mutations and posttranslational modifications (PTMs) of the …
diseases, including cancer. Mutations and posttranslational modifications (PTMs) of the …
[HTML][HTML] Upregulation of FAM83F by c-Myc promotes cervical cancer growth and aerobic glycolysis via Wnt/β-catenin signaling activation
C Zhang, L Liu, W Li, M Li, X Zhang, C Zhang… - Cell Death & …, 2023 - nature.com
Cervical cancer (CC) seriously affects women's health. Therefore, elucidation of the exact
mechanisms and identification of novel therapeutic targets are urgently needed. In this …
mechanisms and identification of novel therapeutic targets are urgently needed. In this …
[HTML][HTML] The PRMT5-LSD1 axis confers Slug dual transcriptional activities and promotes breast cancer progression
J Zhang, X Fan, Y Zhou, L Chen, H Rao - Journal of Experimental & …, 2022 - Springer
Background Downregulation of epithelial markers and upregulation of mesenchymal
markers are the characteristics of the epithelial to mesenchymal transition (EMT) program …
markers are the characteristics of the epithelial to mesenchymal transition (EMT) program …
[HTML][HTML] Promising role of protein arginine methyltransferases in overcoming anti-cancer drug resistance
Y Zhu, T Xia, DQ Chen, X Xiong, L Shi, Y Zuo… - Drug Resistance …, 2023 - Elsevier
Drug resistance remains a major challenge in cancer treatment, necessitating the
development of novel strategies to overcome it. Protein arginine methyltransferases …
development of novel strategies to overcome it. Protein arginine methyltransferases …
[HTML][HTML] Long noncoding RNA SNHG4: A novel target in human diseases
Q Chu, X Gu, Q Zheng, Z Guo, D Shan, J Wang… - Cancer Cell …, 2021 - Springer
Recently, long noncoding RNAs (lncRNAs) have attracted great attention from researchers.
LncRNAs are non-protein-coding RNAs of more than 200 nucleotides in length. Multiple …
LncRNAs are non-protein-coding RNAs of more than 200 nucleotides in length. Multiple …
[HTML][HTML] PRMT5 disruption drives antitumor immunity in cervical cancer by reprogramming T cell-mediated response and regulating PD-L1 expression
Y Jiang, Y Yuan, M Chen, S Li, J Bai, Y Zhang… - Theranostics, 2021 - ncbi.nlm.nih.gov
Rationale: Protein arginine methyltransferase 5 (PRMT5) is an oncogene that promotes
tumor cell proliferation, invasion and metastasis. However, the underlying mechanisms by …
tumor cell proliferation, invasion and metastasis. However, the underlying mechanisms by …