[HTML][HTML] Pharmacological inhibition of Factor XIIa attenuates abdominal aortic aneurysm, reduces atherosclerosis, and stabilizes atherosclerotic plaques

AK Searle, YC Chen, M Wallert… - Thrombosis and …, 2022 - thieme-connect.com
Background 3F7 is a monoclonal antibody targeting the enzymatic pocket of activated factor
XII (FXIIa), thereby inhibiting its catalytic activity. Given the emerging role of FXIIa in …

Angiotensin‐(1‐7) mitigated angiotensin II‐induced abdominal aortic aneurysms in apolipoprotein E‐knockout mice

F Xue, J Yang, J Cheng, W Sui, C Cheng… - British Journal of …, 2020 - Wiley Online Library
Background and Purpose To test the hypothesis that angiotensin‐(1‐7)[Ang‐(1‐7)] may
attenuate abdominal aortic aneurysm (AAA) via inhibiting vascular inflammation …

Photocrosslinking of adventitial collagen in the porcine abdominal aorta: a preliminary approach to a strategy for prevention of aneurysmal rupture

TV Chirila, S Suzuki - Designs, 2022 - mdpi.com
This study was aimed at generating data for designing a potential method to prevent the
rupture of the abdominal aortic aneurysm (AAA). We found that the mechanical strength and …

Ultraviolet-induced mechanical augmentation of the degraded porcine aortic adventitia: Its significance for preventing aneurysmal rupture

TV Chirila, S Suzuki - Global Translational Medicine, 2023 - accscience.com
In the previous studies, we have shown that the tunica adventitia of porcine abdominal aorta
could be mechanically reinforced by irradiating it with ultraviolet A (UV-A) rays to promote …

The detrimental role of intraluminal thrombus outweighs protective advantage in abdominal aortic aneurysm pathogenesis: the implications for the anti-platelet therapy

X Ma, S Xia, G Liu, C Song - Biomolecules, 2022 - mdpi.com
Abdominal aortic aneurysm (AAA) is a common cardiovascular disease resulting in
morbidity and mortality in older adults due to rupture. Currently, AAA treatment relies entirely …

[HTML][HTML] Gold nanoparticles that target degraded elastin improve imaging and rupture prediction in an AngII mediated mouse model of abdominal aortic aneurysm

X Wang, BA Lane, JF Eberth, SM Lessner… - Theranostics, 2019 - ncbi.nlm.nih.gov
Background: Abdominal aortic aneurysms (AAA) are characterized by a progressive
disruption and weakening of the extracellular matrix (ECM) leading to dilation of the aorta …

Synchronous and metachronous thoracic aortic aneurysms in patients with abdominal aortic aneurysms: a systematic review and meta‐analysis

R Gouveia e Melo, G Silva Duarte, A Lopes… - Journal of the …, 2020 - Am Heart Assoc
Background The prevalence of thoracic aortic aneurysms (TAA) in patients with known
abdominal aortic aneurysms (AAA) is not well known and understudied. Our aim was to …

The Effect of One Year Aneurysm Sac Dynamics on Five Year Mortality and Continued Aneurysm Sac Evolution

C Li, D Böckler, V Rastogi, HJM Verhagen… - European Journal of …, 2024 - Elsevier
Objective One year aneurysm sac dynamics after endovascular abdominal aortic aneurysm
repair (EVAR) were independently associated with greater risk of all-cause mortality in prior …

Caught Between Heart and Limbs: Navigating the Treatment of Patients With CAD and PAD in an Overwhelmed Healthcare System

P Dabic, J Petrovic, B Vucurevic, A Bucic… - …, 2023 - journals.sagepub.com
Peripheral arterial disease (PAD) and coronary artery disease (CAD) are manifestations of
atherosclerosis, affecting a substantial proportion of the population. Despite their …

A novel hypothesis: A role for follicle stimulating hormone in abdominal aortic aneurysm development in postmenopausal women

VN Tedjawirja, M Nieuwdorp, KK Yeung… - Frontiers in …, 2021 - frontiersin.org
An abdominal aortic aneurysm (AAA) is a dilatation of the abdominal aorta, which can
potentially be fatal due to exsanguination following rupture. Although AAA is less prevalent …