Endothelium structure and function in kidney health and disease

N Jourde-Chiche, F Fakhouri, L Dou, J Bellien… - Nature Reviews …, 2019 - nature.com
The kidney harbours different types of endothelia, each with specific structural and functional
characteristics. The glomerular endothelium, which is highly fenestrated and covered by a …

Complement system part I–molecular mechanisms of activation and regulation

NS Merle, SE Church, V Fremeaux-Bacchi… - Frontiers in …, 2015 - frontiersin.org
Complement is a complex innate immune surveillance system, playing a key role in defense
against pathogens and in host homeostasis. The complement system is initiated by …

[HTML][HTML] Atypical hemolytic uremic syndrome and C3 glomerulopathy: conclusions from a “Kidney Disease: Improving Global Outcomes”(KDIGO) Controversies …

THJ Goodship, HT Cook, F Fakhouri, FC Fervenza… - Kidney international, 2017 - Elsevier
In both atypical hemolytic uremic syndrome (aHUS) and C3 glomerulopathy (C3G)
complement plays a primary role in disease pathogenesis. Herein we report the outcome of …

Complement system part II: role in immunity

NS Merle, R Noe, L Halbwachs-Mecarelli… - Frontiers in …, 2015 - frontiersin.org
The complement system has been considered for a long time as a simple lytic cascade,
aimed to kill bacteria infecting the host organism. Nowadays, this vision has changed and it …

Thrombotic microangiopathy in aHUS and beyond: clinical clues from complement genetics

F Fakhouri, V Frémeaux-Bacchi - Nature Reviews Nephrology, 2021 - nature.com
Studies of complement genetics have changed the landscape of thrombotic
microangiopathies (TMAs), particularly atypical haemolytic uraemic syndrome (aHUS) …

Complement activation, regulation, and molecular basis for complement‐related diseases

G Bajic, SE Degn, S Thiel, GR Andersen - The EMBO journal, 2015 - embopress.org
The complement system is an essential element of the innate immune response that
becomes activated upon recognition of molecular patterns associated with microorganisms …

Thrombocytopenia in pregnancy

DB Cines, LD Levine - Hematology 2014, the American Society …, 2017 - ashpublications.org
Abstract Thrombocytopenia develops in 5% to 10% of women during pregnancy or in the
immediate postpartum period. A low platelet count is often an incidental feature, but it might …

C3‐dependent effector functions of complement

A Zarantonello, M Revel, A Grunenwald… - Immunological …, 2023 - Wiley Online Library
C3 is the central effector molecule of the complement system, mediating its multiple
functions through different binding sites and their corresponding receptors. We will introduce …

Haemolytic uraemic syndrome

D Karpman, S Loos, R Tati… - Journal of internal …, 2017 - Wiley Online Library
Haemolytic uraemic syndrome (HUS) is defined by the simultaneous occurrence of
nonimmune haemolytic anaemia, thrombocytopenia and acute renal failure. This leads to …

Complement in thrombotic microangiopathies: unraveling Ariadne's thread into the labyrinth of complement therapeutics

E Gavriilaki, A Anagnostopoulos… - Frontiers in …, 2019 - frontiersin.org
Thrombotic microangiopathies (TMAs) are a heterogeneous group of syndromes presenting
with a distinct clinical triad: microangiopathic hemolytic anemia, thrombocytopenia, and …