Endothelium structure and function in kidney health and disease
N Jourde-Chiche, F Fakhouri, L Dou, J Bellien… - Nature Reviews …, 2019 - nature.com
The kidney harbours different types of endothelia, each with specific structural and functional
characteristics. The glomerular endothelium, which is highly fenestrated and covered by a …
characteristics. The glomerular endothelium, which is highly fenestrated and covered by a …
Complement system part I–molecular mechanisms of activation and regulation
NS Merle, SE Church, V Fremeaux-Bacchi… - Frontiers in …, 2015 - frontiersin.org
Complement is a complex innate immune surveillance system, playing a key role in defense
against pathogens and in host homeostasis. The complement system is initiated by …
against pathogens and in host homeostasis. The complement system is initiated by …
[HTML][HTML] Atypical hemolytic uremic syndrome and C3 glomerulopathy: conclusions from a “Kidney Disease: Improving Global Outcomes”(KDIGO) Controversies …
THJ Goodship, HT Cook, F Fakhouri, FC Fervenza… - Kidney international, 2017 - Elsevier
In both atypical hemolytic uremic syndrome (aHUS) and C3 glomerulopathy (C3G)
complement plays a primary role in disease pathogenesis. Herein we report the outcome of …
complement plays a primary role in disease pathogenesis. Herein we report the outcome of …
Complement system part II: role in immunity
NS Merle, R Noe, L Halbwachs-Mecarelli… - Frontiers in …, 2015 - frontiersin.org
The complement system has been considered for a long time as a simple lytic cascade,
aimed to kill bacteria infecting the host organism. Nowadays, this vision has changed and it …
aimed to kill bacteria infecting the host organism. Nowadays, this vision has changed and it …
Thrombotic microangiopathy in aHUS and beyond: clinical clues from complement genetics
F Fakhouri, V Frémeaux-Bacchi - Nature Reviews Nephrology, 2021 - nature.com
Studies of complement genetics have changed the landscape of thrombotic
microangiopathies (TMAs), particularly atypical haemolytic uraemic syndrome (aHUS) …
microangiopathies (TMAs), particularly atypical haemolytic uraemic syndrome (aHUS) …
Complement activation, regulation, and molecular basis for complement‐related diseases
The complement system is an essential element of the innate immune response that
becomes activated upon recognition of molecular patterns associated with microorganisms …
becomes activated upon recognition of molecular patterns associated with microorganisms …
Thrombocytopenia in pregnancy
DB Cines, LD Levine - Hematology 2014, the American Society …, 2017 - ashpublications.org
Abstract Thrombocytopenia develops in 5% to 10% of women during pregnancy or in the
immediate postpartum period. A low platelet count is often an incidental feature, but it might …
immediate postpartum period. A low platelet count is often an incidental feature, but it might …
C3‐dependent effector functions of complement
A Zarantonello, M Revel, A Grunenwald… - Immunological …, 2023 - Wiley Online Library
C3 is the central effector molecule of the complement system, mediating its multiple
functions through different binding sites and their corresponding receptors. We will introduce …
functions through different binding sites and their corresponding receptors. We will introduce …
Haemolytic uraemic syndrome
D Karpman, S Loos, R Tati… - Journal of internal …, 2017 - Wiley Online Library
Haemolytic uraemic syndrome (HUS) is defined by the simultaneous occurrence of
nonimmune haemolytic anaemia, thrombocytopenia and acute renal failure. This leads to …
nonimmune haemolytic anaemia, thrombocytopenia and acute renal failure. This leads to …
Complement in thrombotic microangiopathies: unraveling Ariadne's thread into the labyrinth of complement therapeutics
E Gavriilaki, A Anagnostopoulos… - Frontiers in …, 2019 - frontiersin.org
Thrombotic microangiopathies (TMAs) are a heterogeneous group of syndromes presenting
with a distinct clinical triad: microangiopathic hemolytic anemia, thrombocytopenia, and …
with a distinct clinical triad: microangiopathic hemolytic anemia, thrombocytopenia, and …