Epigenetic clocks comprise a set of CpG sites whose DNA methylation levels measure
subject age. These clocks are acknowledged as a highly accurate molecular correlate of …

This review describes new developments in the study of transgenerational epigenetic
inheritance, a component of epigenetics. We start by examining the basic concepts of the …

Natural epigenetic variation provides a source for the generation of phenotypic diversity, but
to understand its contribution to such diversity, its interaction with genetic variation requires …

DNA methylation plays an important role in epigenetic signalling, having an impact on gene
regulation, chromatin structure, development and disease. Here, we review the structures …

Phenotypic variation is traditionally parsed into components that are directed by genetic and
environmental variation. The line between these two components is blurred by inherited …

The enzymatic control of the setting and maintenance of symmetric and non-symmetric DNA
methylation patterns in a particular genome context is not well understood. Here, we …

Global demethylation is part of a conserved program of epigenetic reprogramming to naive
pluripotency. The transition from primed hypermethylated embryonic stem cells (ESCs) to …

DNA methylation is considered a stable epigenetic mark, yet methylation patterns can vary
during differentiation and in diseases such as cancer. Local levels of DNA methylation result …

The regulation of gene expression plays a pivotal role in complex phenotypes, and
epigenetic mechanisms such as DNA methylation are essential to this process. The …

In vertebrates, methylation of cytosine at CpG sequences is implicated in stable and
heritable patterns of gene expression. The classical model for inheritance, in which …