DNA demethylation can occur passively by “dilution” of methylation marks by DNA
replication, or actively and independently of DNA replication. Direct conversion of 5 …

Multicellular organisms developed the concept of specialized cells that perform specific
functions. Examples are neurons and fibroblast to name just two out of more than 200 …

While some DNA base modifications such as 5-methylcytosine have been known and
studied for decades, recent discoveries of a number of other modified bases have stimulated …

AID/APOBEC family enzymes are best known for deaminating cytosine bases to uracil in
single-stranded DNA, with characteristic sequence preferences that can produce mutational …

Changes in DNA methylation are required for the formation of germinal centers (GCs), but
the mechanisms of such changes are poorly understood. Activation-induced cytidine …

In DNA, the loss of a nucleobase by hydrolysis generates an abasic site. Formed as a result
of DNA damage, as well as a key intermediate during the base excision repair pathway …

Pathways that control and modulate DNA methylation patterning in mammalian cells were
poorly understood for a long time, although their importance in establishing and maintaining …

Epigenetic heterogeneity is emerging as a feature of tumors. In diffuse large B-cell
lymphoma (DLBCL), increased cytosine methylation heterogeneity is associated with poor …

The aim of this review is to describe the reactions which lead to generation of 5-
hydroxymethyluracil, as well as the repair processes involved in its removal from DNA, and …

Epigenetic plasticity underpins cell potency, but the extent to which active turnover of DNA
methylation contributes to such plasticity is not known, and the underlying pathways are …