The biophysical role of hemodynamics in the pathogenesis of cerebral aneurysm formation and rupture

S Soldozy, P Norat, M Elsarrag, A Chatrath… - Neurosurgical …, 2019 - thejns.org
The pathogenesis of intracranial aneurysms remains complex and multifactorial. While
vascular, genetic, and epidemiological factors play a role, nascent aneurysm formation is …

How patient specific are patient-specific computational models of cerebral aneurysms? An overview of sources of error and variability

DA Steinman, VM Pereira - Neurosurgical focus, 2019 - thejns.org
Computational modeling of cerebral aneurysms, derived from clinical 3D angiography, has
become widespread over the past 15 years. While such “image-based” or “patient-specific” …

Real-world variability in the prediction of intracranial aneurysm wall shear stress: the 2015 international aneurysm CFD challenge

K Valen-Sendstad, AW Bergersen… - Cardiovascular …, 2018 - Springer
Purpose Image-based computational fluid dynamics (CFD) is widely used to predict
intracranial aneurysm wall shear stress (WSS), particularly with the goal of improving rupture …

Better than nothing: a rational approach for minimizing the impact of outflow strategy on cerebrovascular simulations

C Chnafa, O Brina, VM Pereira… - American journal of …, 2018 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: Computational fluid dynamics simulations of
neurovascular diseases are impacted by various modeling assumptions and uncertainties …

Multiple aneurysms anatomy challenge 2018 (MATCH): phase I: segmentation

P Berg, S Voß, S Saalfeld, G Janiga… - Cardiovascular …, 2018 - Springer
Purpose Advanced morphology analysis and image-based hemodynamic simulations are
increasingly used to assess the rupture risk of intracranial aneurysms (IAs). However, the …

The computational fluid dynamics rupture challenge 2013—phase II: variability of hemodynamic simulations in two intracranial aneurysms

P Berg, C Roloff, O Beuing… - Journal of …, 2015 - asmedigitalcollection.asme.org
With the increased availability of computational resources, the past decade has seen a rise
in the use of computational fluid dynamics (CFD) for medical applications. There has been …

A review on the reliability of hemodynamic modeling in intracranial aneurysms: why computational fluid dynamics alone cannot solve the equation

P Berg, S Saalfeld, S Voß, O Beuing, G Janiga - Neurosurgical focus, 2019 - thejns.org
Computational blood flow modeling in intracranial aneurysms (IAs) has enormous potential
for the assessment of highly resolved hemodynamics and derived wall stresses. This results …

Basic principles of hemodynamics and cerebral aneurysms

PM Munarriz, PA Gómez, I Paredes… - World neurosurgery, 2016 - Elsevier
Background Rupture is the most serious consequence of cerebral aneurysms, and its
likelihood depends on nonmodifiable and modifiable risk factors. Recent efforts have …

Blood flow into basilar tip aneurysms: a predictor for recanalization after coil embolization

S Sugiyama, K Niizuma, K Sato, S Rashad, M Kohama… - Stroke, 2016 - Am Heart Assoc
Background and Purpose—Hemodynamic forces may play a role in the recanalization of
coiled aneurysms. The purpose of this study was to investigate the influence of presurgical …

Comparison of intracranial aneurysm flow quantification techniques: standard PIV vs stereoscopic PIV vs tomographic PIV vs phase-contrast MRI vs CFD

C Roloff, D Stucht, O Beuing, P Berg - Journal of neurointerventional …, 2019 - jnis.bmj.com
Image-based hemodynamic simulations to assess the rupture risk or improve the treatment
planning of intracranial aneurysms have become popular recently. However, due to strong …