Recent advances in genomic technology have led to a better understanding of key
molecular alterations that underlie glioblastoma (GBM). The current WHO-based …

Background Limitless self-renewal is one of the hallmarks of cancer and is attained by
telomere maintenance, essentially through telomerase (h TERT) activation. Transcriptional …

The establishment of DNA methylation patterns requires de novo methylation that occurs
predominantly during early development and gametogenesis in mice. Here we demonstrate …

Epigenetic regulation of hematopoietic stem cells (HSCs) ensures lifelong production of
blood and bone marrow. Recently, we reported that loss of de novo DNA methyltransferase …

Roger D. Kornberg* and Yahli Lorch Department of Structural Biology Stanford University
School of Medicine Stanford, California 94305 model building and other predictive structural …

In conjunction with histone modifications, DNA methylation plays critical roles in gene
silencing through chromatin remodeling. Changes in DNA methylation perturb neuronal …

Recently, the concept that epigenetic, as well as genetic, events might be central to the
evolution of human cancer is re-emerging. Cancers often exhibit an aberrant methylation of …

Epigenetics is the study of heritable changes in gene expression that occur without a
change in DNA sequence. Epigenetic phenomena have major economic and medical …

Long-term memory formation requires selective changes in gene expression. Here, we
determined the contribution of chromatin remodeling to learning-induced changes in brain …

Gene function in cancer can be disrupted either through genetic alterations, which directly
mutate or delete genes, or epigenetic alterations, which alter the heritable state of gene …