Abdominal aortic aneurysm (AAA) rupture is an important cause of death in adults. Currently,
the only treatment for AAA is open or endovascular surgical repair. In most parts of the …

Prompted by the observation that atherosclerotic plaques from human diabetic subjects
displayed lower amounts of NADPH (nicotinamide adenine dinucleotide phosphate) …

Aortic aneurysm is a life-threatening disease due to the risk of aortic rupture. The only
curative treatment available relies on surgical approaches; drug-based therapies are …

A variety of animal models have been developed to better understand the pathophysiology
of AAA. The 3 most commonly used mouse AAA models are adventitial exposure to calcium …

Abdominal aortic aneurysm (AAA) is a severe vascular disease and a major public health
issue with an unmet medical need for therapy. This disease is featured by a progressive …

Macrophages have a key functional role in the pathogenesis of various cardiovascular
diseases, such as atherosclerosis and aortic aneurysms. Their accumulation within the …

Neutrophils represent up to 70% of circulating leukocytes in healthy humans and combat
infection mostly by phagocytosis, degranulation and NETosis. It has been reported that …

Importance Small abdominal aortic aneurysms (AAAs) are common in the elderly
population. Their growth rates and patterns, which drive clinical surveillance, are widely …

Introduction: Diabetes mellitus is recognised as a significant risk factor for cardiovascular
and peripheral vascular disease, as the abnormal metabolic state increases the risk for …

Abdominal aortic aneurysm (AAA) is a complex disease which is incompletely accounted for.
Basement membrane (BM) Collagen IV (COL4A1/A2) is abundant in the artery wall, and …