The Global Decline in Human Fertility: The Post-Transition Trap Hypothesis

RJ Aitken - Life, 2024 - mdpi.com
Over the past half a century many countries have witnessed a rapid fall in total fertility rates,
particularly in the world's most advanced economies including the industrial powerhouses of …

Molecular Mechanism of Oocyte Activation in Mammals: Past, Present, and Future Directions

H Sugita, S Takarabe, A Kageyama, Y Kawata, J Ito - Biomolecules, 2024 - mdpi.com
During mammalian fertilization, repetitive intracellular Ca2+ increases known as Ca2+
oscillations occur. These oscillations are considered crucial for successful fertilization and …

A DNA Methylation Perspective on Infertility

G Shacfe, R Turko, HH Syed, I Masoud, Y Tahmaz… - Genes, 2023 - mdpi.com
Infertility affects a significant number of couples worldwide and its incidence is increasing.
While assisted reproductive technologies (ART) have revolutionized the treatment …

Early rescue oocyte activation at 5 h post-ICSI is a useful strategy for avoiding unexpected fertilization failure and low fertilization in ICSI cycles

L Xue, S Wang, P Wei, H Liu, X Mao, J Qin… - Frontiers in …, 2024 - frontiersin.org
Introduction Attempts to artificially activate unfertilized oocytes at 24 h post intracytoplasmic
sperm injection (ICSI) have generally resulted in poor outcomes. This study aims to explore …

Intracytoplasmic sperm injection is still the best management of male factor infertility

P Xie, S Cheung, O Kocur, L Ng, A De Jesus… - Fertility and …, 2024 - fertstert.org
Intracytoplasmic sperm injection (ICSI) has affirmed itself as a groundbreaking technique to
treat severe male factor infertility that could not be effectively managed by conventional in …

[HTML][HTML] Novel Nuclear Roles for Testis-Specific ACTL7A and ACTL7B Supported by In Vivo Characterizations and AI Facilitated In Silico Mechanistic Modeling with …

P Ferrer, S Upadhyay, JJ Cai, TM Clement - bioRxiv, 2024 - ncbi.nlm.nih.gov
A mechanistic role for nuclear function of testis-specific actin related proteins (ARPs) is
proposed here through contributions of ARP subunit swapping in canonical chromatin …

Diagnostic or prognostic? Decoding the role of embryo selection on in vitro fertilization treatment outcomes

H Zou, R Wang, DE Morbeck - Fertility and Sterility, 2024 - Elsevier
In this review, we take a fresh look at embryo assessment and selection methods from the
perspective of diagnosis and prognosis. On the basis of a systematic search in the literature …

[HTML][HTML] The growing importance of genetics in human reproduction and development

D Ježek - Croatian Medical Journal, 2023 - ncbi.nlm.nih.gov
Human reproduction and growth depend on normal developmental processes such as the
production of competent gametes, fertilization, embryonic development, pregnancy, and …

[HTML][HTML] Perspective Chapter: Application of Abnormally Fertilized Eggs and the Associated Clinical Outcomes

B Wu, X Feng, S Lu, TJ Gelety - 2024 - intechopen.com
Human IVF laboratory often shows many abnormal fertilization eggs, such as no pronucleus
(0PN), monopronucleus (1PN), three pronuclei (3PN) or multi-pronuclei (mPN) zygotes and …

Clinical and laboratory characteristics of patients with embryonic arrest in the early embryonic period of in vitro fertilization programs

MT Pogosyan, TA Nazarenko… - Obstetrics and …, 2024 - journals.eco-vector.com
Objective: To investigate the clinical and hormonal parameters and outcomes of in vitro
fertilization (IVF) programs in patients with impaired embryo cleavage compared to those in …