DNA methylation dynamics in health and disease
Y Bergman, H Cedar - Nature structural & molecular biology, 2013 - nature.com
DNA methylation is an epigenetic mark that is erased in the early embryo and then re-
established at the time of implantation. In this Review, dynamics of DNA methylation during …
established at the time of implantation. In this Review, dynamics of DNA methylation during …
Promoter DNA hypermethylation and paradoxical gene activation
DNA methylation is a stable epigenetic modification that contributes to the spatiotemporal
regulation of gene expression. The manner in which DNA methylation contributes to …
regulation of gene expression. The manner in which DNA methylation contributes to …
[HTML][HTML] Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair
S Cortellino, J Xu, M Sannai, R Moore, E Caretti… - Cell, 2011 - cell.com
DNA methylation is a major epigenetic mechanism for gene silencing. Whereas
methyltransferases mediate cytosine methylation, it is less clear how unmethylated regions …
methyltransferases mediate cytosine methylation, it is less clear how unmethylated regions …
DNMT1 and DNMT3b cooperate to silence genes in human cancer cells
I Rhee, KE Bachman, BH Park, KW Jair, RWC Yen… - Nature, 2002 - nature.com
Inactivation of tumour suppressor genes is central to the development of all common forms
of human cancer 1. This inactivation often results from epigenetic silencing associated with …
of human cancer 1. This inactivation often results from epigenetic silencing associated with …
Control of CpNpG DNA methylation by the KRYPTONITE histone H3 methyltransferase
Gene silencing in eukaryotes is associated with the formation of heterochromatin, a complex
of proteins and DNA that block transcription. Heterochromatin is characterized by the …
of proteins and DNA that block transcription. Heterochromatin is characterized by the …
[图书][B] Chromatin: structure and function
A Wolffe - 1998 - books.google.com
The Third Edition of Chromatin: Structure and Function brings the reader up-to-date with the
remarkable progress in chromatin research over the past three years. It has been …
remarkable progress in chromatin research over the past three years. It has been …
Beyond Watson and Crick: DNA methylation and molecular enzymology of DNA methyltransferases
A Jeltsch - Chembiochem, 2002 - Wiley Online Library
DNA methyltransferases catalyze the transfer of a methyl group from S‐adenosyl‐l‐
methionine to cytosine or adenine bases in DNA. These enzymes challenge the …
methionine to cytosine or adenine bases in DNA. These enzymes challenge the …
Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia
S Ferber, A Halkin, H Cohen, I Ber, Y Einav… - Nature medicine, 2000 - nature.com
Insulin gene expression is restricted to islet β cells of the mammalian pancreas through
specific control mechanisms mediated in part by specific transcription factors 1, 2. The …
specific control mechanisms mediated in part by specific transcription factors 1, 2. The …
Conserved epigenetic sensitivity to early life experience in the rat and human hippocampus
M Suderman, PO McGowan, A Sasaki… - Proceedings of the …, 2012 - National Acad Sciences
Early life experience is associated with long-term effects on behavior and epigenetic
programming of the NR3C1 (GLUCOCORTICOID RECEPTOR) gene in the hippocampus of …
programming of the NR3C1 (GLUCOCORTICOID RECEPTOR) gene in the hippocampus of …
DNA methylation
R Singal, GD Ginder - Blood, The Journal of the American …, 1999 - ashpublications.org
SINCE ITS FIRST recognition in 1948, the fifth base of human DNA, 5-methylcytosine (5-mC)
has generated much interest and considerable controversy during attempts to understand its …
has generated much interest and considerable controversy during attempts to understand its …