The unique characteristics of COVID-19 coagulopathy

T Iba, JH Levy, JM Connors, TE Warkentin, J Thachil… - Critical care, 2020 - Springer
Thrombotic complications and coagulopathy frequently occur in COVID-19. However, the
characteristics of COVID-19-associated coagulopathy (CAC) are distinct from those seen …

Coagulopathy and sepsis: Pathophysiology, clinical manifestations and treatment

M Giustozzi, H Ehrlinder, D Bongiovanni, JA Borovac… - Blood reviews, 2021 - Elsevier
Sepsis is a complex syndrome with a high incidence, increasing by 8.7% annually over the
last 20 years. Coagulopathy is a leading factor associated with mortality in patients with …

The emerging spectrum of cardiopulmonary pathology of the coronavirus disease 2019 (COVID-19): Report of 3 autopsies from Houston, Texas, and review of autopsy …

LM Buja, DA Wolf, B Zhao, B Akkanti… - Cardiovascular …, 2020 - Elsevier
This paper collates the pathological findings from initial published autopsy reports on 23
patients with coronavirus disease 2019 (COVID-19) from 5 centers in the United States of …

A novel treatment approach to the novel coronavirus: an argument for the use of therapeutic plasma exchange for fulminant COVID-19

P Keith, M Day, L Perkins, L Moyer, K Hewitt, A Wells - Critical Care, 2020 - Springer
The novel coronavirus (“SARS-CoV-2”) outbreak has created a sense of panic globally and
has the medical community rapidly searching for answers. An estimated 100,000 individuals …

[HTML][HTML] Therapeutic plasma exchange in adults with severe COVID-19 infection

F Khamis, I Al-Zakwani, S Al Hashmi… - International Journal of …, 2020 - Elsevier
Objective To evaluate the therapeutic use of plasma exchange in COVID-19 patients
compared to controls. Methods A case series of critically ill adult men and non-pregnant …

Endothelial injury and glycocalyx degradation in critically ill coronavirus disease 2019 patients: implications for microvascular platelet aggregation

DD Fraser, EK Patterson, M Slessarev… - Critical Care …, 2020 - journals.lww.com
Objectives: Coronavirus disease 2019 is caused by the novel severe acute respiratory
syndrome coronavirus 2 virus. Patients admitted to the ICU suffer from microvascular …

The pathophysiology of SARS-CoV-2: A suggested model and therapeutic approach

G Morris, CC Bortolasci, BK Puri, L Olive, W Marx… - Life sciences, 2020 - Elsevier
In this paper, a model is proposed of the pathophysiological processes of COVID-19 starting
from the infection of human type II alveolar epithelial cells (pneumocytes) by SARS-CoV-2 …

Parallels in sepsis and COVID-19 conditions: implications for managing severe COVID-19

CO Olwal, NN Nganyewo, K Tapela… - Frontiers in …, 2021 - frontiersin.org
Sepsis is a life-threatening systemic illness attributed to a dysregulated host response to
infection. Sepsis is a global burden killing~ 11 million persons annually. In December 2019 …

The role of endothelial shear stress on haemodynamics, inflammation, coagulation and glycocalyx during sepsis

F Lupu, G Kinasewitz, K Dormer - Journal of cellular and …, 2020 - Wiley Online Library
Sepsis is a multifactorial syndrome primarily determined by the host response to an invading
pathogen. It is common, with over 48 million cases worldwide in 2017, and often lethal. The …

The cytokine storms of COVID-19, H1N1 influenza, CRS and MAS compared. Can one sized treatment fit all?

G Morris, CC Bortolasci, BK Puri, W Marx, A O'Neil… - Cytokine, 2021 - Elsevier
An analysis of published data appertaining to the cytokine storms of COVID-19, H1N1
influenza, cytokine release syndrome (CRS), and macrophage activation syndrome (MAS) …