Induced pluripotent stem cells in disease modelling and drug discovery
The derivation of induced pluripotent stem cells (iPSCs) over a decade ago sparked
widespread enthusiasm for the development of new models of human disease, enhanced …
widespread enthusiasm for the development of new models of human disease, enhanced …
[HTML][HTML] Current challenges of iPSC-based disease modeling and therapeutic implications
MX Doss, A Sachinidis - Cells, 2019 - mdpi.com
Induced pluripotent stem cell (iPSC)-based disease modelling and the cell replacement
therapy approach have proven to be very powerful and instrumental in biomedical research …
therapy approach have proven to be very powerful and instrumental in biomedical research …
[HTML][HTML] The glioma stem cell model in the era of single-cell genomics
Glioma stem cells (GSCs) are thought to underlie glioma initiation, evolution, and resistance
to existing therapies. Although functional evidence for GSCs is abundant, tumor …
to existing therapies. Although functional evidence for GSCs is abundant, tumor …
[HTML][HTML] Reconstructing and reprogramming the tumor-propagating potential of glioblastoma stem-like cells
Developmental fate decisions are dictated by master transcription factors (TFs) that interact
with cis-regulatory elements to direct transcriptional programs. Certain malignant tumors …
with cis-regulatory elements to direct transcriptional programs. Certain malignant tumors …
[HTML][HTML] Mesenchymal differentiation mediated by NF-κB promotes radiation resistance in glioblastoma
KPL Bhat, V Balasubramaniyan, B Vaillant… - Cancer cell, 2013 - cell.com
Despite extensive study, few therapeutic targets have been identified for glioblastoma
(GBM). Here we show that patient-derived glioma sphere cultures (GSCs) that resemble …
(GBM). Here we show that patient-derived glioma sphere cultures (GSCs) that resemble …
Chromatin dynamics during cellular reprogramming
E Apostolou, K Hochedlinger - Nature, 2013 - nature.com
Induced pluripotency is a powerful tool to derive patient-specific stem cells. In addition, it
provides a unique assay to study the interplay between transcription factors and chromatin …
provides a unique assay to study the interplay between transcription factors and chromatin …
Age-associated epigenetic drift: implications, and a case of epigenetic thrift?
It is now well established that the genomic landscape of DNA methylation (DNAm) gets
altered as a function of age, a process we here call 'epigenetic drift'. The biological …
altered as a function of age, a process we here call 'epigenetic drift'. The biological …
[HTML][HTML] An aberrant transcription factor network essential for Wnt signaling and stem cell maintenance in glioblastoma
Glioblastoma (GBM) is thought to be driven by a subpopulation of cancer stem cells (CSCs)
that self-renew and recapitulate tumor heterogeneity yet remain poorly understood. Here, we …
that self-renew and recapitulate tumor heterogeneity yet remain poorly understood. Here, we …
[HTML][HTML] The lncRNA TP73-AS1 is linked to aggressiveness in glioblastoma and promotes temozolomide resistance in glioblastoma cancer stem cells
Glioblastoma multiform (GBM) is the most common brain tumor characterized by a dismal
prognosis. GBM cancer stem cells (gCSC) or tumor-initiating cells are the cell population …
prognosis. GBM cancer stem cells (gCSC) or tumor-initiating cells are the cell population …
Present and future challenges of induced pluripotent stem cells
M Ohnuki, K Takahashi - Philosophical Transactions of …, 2015 - royalsocietypublishing.org
Growing old is our destiny. However, the mature differentiated cells making up our body can
be rejuvenated to an embryo-like fate called pluripotency which is an ability to differentiate …
be rejuvenated to an embryo-like fate called pluripotency which is an ability to differentiate …