Melatonin is a pineal indolamine, allegedly known as a circadian rhythm regulator, and an
antioxidative and immunomodulatory molecule. In both experimental and clinical trials …

Numerous pharmaceutical drugs have been repurposed for use as treatments for COVID-19
disease. These drugs have not consistently demonstrated high efficacy in preventing or …

Melatonin, a product of tryptophan metabolism via serotonin, is a molecule with an indole
backbone that is widely produced by bacteria, unicellular eukaryotic organisms, plants, fungi …

Septic cardiomyopathy (SCM) is a common complication of sepsis contributing to high
mortality rates. Its pathophysiology involves complex factors, including inflammatory …

Background Immunotransmitters (eg, neurotransmitters and neuromodulators) could
orchestrate diverse immune responses; however, the elaborated mechanism by which …

Circadian rhythms are present in almost every organism and regulate multiple aspects of
biological and physiological processes (eg metabolism, immune responses, and microbial …

Sepsis is a potentially fatal condition characterized by organ dysfunction caused by an
imbalanced immune response to infection. Although an increased inflammatory response …

Periodontitis as a highly prevalent chronic infection/inflammatory disease can eventually
lead to tooth loss and masticatory dysfunction. It also has a negative impact on general …

Multidrug-resistant (MDR) Gram-negative pathogens remain an unmet public health threat.
In recent times, increased rates of resistance have been reported not only to commonly used …

Bacterial infections caused by Gram-negative pathogens represent a growing burden for
public health worldwide. Despite the urgent need for new antibiotics that effectively fight …