Epigenetic tools (The Writers, The Readers and The Erasers) and their implications in cancer therapy
S Biswas, CM Rao - European journal of pharmacology, 2018 - Elsevier
Addition of chemical tags on the DNA and modification of histone proteins impart a distinct
feature on chromatin architecture. With the advancement in scientific research, the key …
feature on chromatin architecture. With the advancement in scientific research, the key …
Methyl-CpG-binding domain proteins: readers of the epigenome
How DNA methylation is interpreted and influences genome regulation remains largely
unknown. Proteins of the methyl-CpG-binding domain (MBD) family are primary candidates …
unknown. Proteins of the methyl-CpG-binding domain (MBD) family are primary candidates …
Evidence that direct inhibition of transcription factor binding is the prevailing mode of gene and repeat repression by DNA methylation
S Kaluscha, S Domcke, C Wirbelauer, MB Stadler… - Nature …, 2022 - nature.com
Cytosine methylation efficiently silences CpG-rich regulatory regions of genes and repeats
in mammalian genomes. To what extent this entails direct inhibition of transcription factor …
in mammalian genomes. To what extent this entails direct inhibition of transcription factor …
TETonic shift: biological roles of TET proteins in DNA demethylation and transcription
In many organisms, the methylation of cytosine in DNA has a key role in silencing'parasitic'
DNA elements, regulating transcription and establishing cellular identity. The recent …
DNA elements, regulating transcription and establishing cellular identity. The recent …
Structure and function of mammalian DNA methyltransferases
DNA methylation plays an important role in epigenetic signalling, having an impact on gene
regulation, chromatin structure, development and disease. Here, we review the structures …
regulation, chromatin structure, development and disease. Here, we review the structures …
Genomic DNA methylation: the mark and its mediators
Methylation of DNA at position five of the cytosine ring occurs at most CpG dinucleotides in
the mammalian genome and is essential for embryonic viability. With several of the key …
the mammalian genome and is essential for embryonic viability. With several of the key …
[HTML][HTML] CpG islands–'a rough guide'
RS Illingworth, AP Bird - FEBS letters, 2009 - Elsevier
Mammalian genomes are punctuated by DNA sequences containing an atypically high
frequency of CpG sites termed CpG islands (CGIs). CGIs generally lack DNA methylation …
frequency of CpG sites termed CpG islands (CGIs). CGIs generally lack DNA methylation …
Transcription regulation by histone methylation: interplay between different covalent modifications of the core histone tails
Y Zhang, D Reinberg - Genes & development, 2001 - genesdev.cshlp.org
In this review, we discuss recent advances made on histone methylation and its diverse
functions in regulating gene expression. Methylation of histone polypeptides might be static …
functions in regulating gene expression. Methylation of histone polypeptides might be static …
JmjC-domain-containing proteins and histone demethylation
Histone methylation has important roles in regulating gene expression and forms part of the
epigenetic memory system that regulates cell fate and identity. Enzymes that directly remove …
epigenetic memory system that regulates cell fate and identity. Enzymes that directly remove …
H19 lncRNA controls gene expression of the Imprinted Gene Network by recruiting MBD1
P Monnier, C Martinet, J Pontis… - Proceedings of the …, 2013 - National Acad Sciences
The H19 gene controls the expression of several genes within the Imprinted Gene Network
(IGN), involved in growth control of the embryo. However, the underlying mechanisms of this …
(IGN), involved in growth control of the embryo. However, the underlying mechanisms of this …