Circular RNAs (circRNAs) are connected at the 3′ and 5′ ends by exon or intron
cyclization, forming a complete ring structure. circRNA is more stable and conservative than …

Hepatocellular carcinoma (HCC) is associated with chronic inflammation and fibrosis arising
from different etiologies, including hepatitis B and C and alcoholic and nonalcoholic fatty …

More than a decade has passed since the conceptualization of the “alarmin” hypothesis. The
alarmin family has been expanding in terms of both number and the concept. It has recently …

Hepatocellular carcinoma (HCC) is a major cause of cancer‐related death worldwide and
currently has the fastest rising incidence of all cancers. Sorafenib was originally identified as …

Our immune system is based on the close collaboration of the innate and adaptive immune
systems for the rapid detection of any threats to the host. Recognition of pathogen-derived …

Complex genetic and physiological variations as well as environmental factors that drive
emergence of chromosomal instability, development of unscheduled cell death, skewed …

Liver cancer ranks the sixth in cancer incidence and the second in tumor related mortality
worldwide, with over half of the new cases and deaths occur in China. Because of difficulties …

High mobility group box 1 (HMGB1) is a nonhistone chromatin-associated protein that has
been widely reported to play a pivotal role in the pathogenesis of hematopoietic …

Abstract Background Regulatory B (Breg) cells represent one of the B cell subsets that
infiltrate solid tumors and exhibit distinct phenotypes in different tumor microenvironments …

Hepatocellular carcinoma (HCC) has become a leading cause of cancer-related death,
making the elucidation of its underlying mechanisms an urgent priority. Inflammation is an …