The epithelium of the mammary gland exists in a highly dynamic state, undergoing dramatic
morphogenetic changes during puberty, pregnancy, lactation, and regression. The recent …

Haematopoietic stem cell (HSC) niches are specialized microenvironments that contain
stem cells and regulate their maintenance. Cells at the interface of bone and the bone …

Application of stem cell biology to breast cancer research has been limited by the lack of
simple methods for identification and isolation of normal and malignant stem cells. Utilizing …

Polycomb group proteins are essential for early development in metazoans, but their
contributions to human development are not well understood. We have mapped the …

Adult stem cells maintain organ systems throughout the course of life and facilitate repair
after injury or disease. A fundamental property of stem and progenitor cell division is the …

The Polycomb group (PcG) proteins form chromatin-modifying complexes that are essential
for embryonic development and stem cell renewal and are commonly deregulated in cancer …

Recent advances have highlighted extensive phenotypic and functional similarities between
normal stem cells and cancer stem cells. This raises the question of whether disease …

Purpose: Breast cancer stem cells have been shown to be associated with resistance to
chemotherapy in vitro, but their clinical significance remains to be clarified. The aim of this …

The role of cytokines in regulation of hematopoietic stem cells (HSCs) remains poorly
understood. Herein we demonstrate that thrombopoietin (THPO) and its receptor, MPL, are …

Stem cells have the ability to differentiate into specific cell types. The 2 defining
characteristics of a stem cell are perpetual self-renewal and the ability to differentiate into a …