[HTML][HTML] Biological impact and therapeutic perspective of targeting PI3K/Akt signaling in hepatocellular carcinoma: Promises and Challenges

MDA Paskeh, F Ghadyani, M Hashemi… - Pharmacological …, 2023 - Elsevier
Cancer progression results from activation of various signaling networks. Among these,
PI3K/Akt signaling contributes to proliferation, invasion, and inhibition of apoptosis …

MicroRNA-mediated regulation of key signaling pathways in hepatocellular carcinoma: A mechanistic insight

LM Ruiz-Manriquez, O Carrasco-Morales… - Frontiers in …, 2022 - frontiersin.org
Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer. The
molecular pathogenesis of HCC varies due to the different etiologies and genotoxic insults …

[HTML][HTML] The suppression of cervical cancer ferroptosis by macrophages: The attenuation of ALOX15 in cancer cells by macrophages-derived exosomes

Y Luo, Y Chen, H Jin, B Hou, H Li, X Li, L Liu… - … Pharmaceutica Sinica B, 2023 - Elsevier
Induction of cancer cell ferroptosis has been proposed as a potential treatment in several
cancer types. Tumor-associated macrophages (TAMs) play a key role in promoting tumor …

miR-660-5p-loaded M2 macrophages-derived exosomes augment hepatocellular carcinoma development through regulating KLF3

BZ Tian, L Zhou, J Wang, P Yang - International Immunopharmacology, 2021 - Elsevier
Abstract Objective M2 macrophages (M2) can affect tumor development by secreting various
cytokines, including exosomes (Exo). Herein, we intended to explore how microRNA (miR) …

A novel therapeutic strategy for hepatocellular carcinoma: Immunomodulatory mechanisms of selenium and/or selenoproteins on a shift towards anti-cancer

BK Wu, QH Chen, D Pan, B Chang, LX Sang - International …, 2021 - Elsevier
Selenium (Se) is an essential trace chemical element that is widely distributed worldwide.
Se exerts its immunomodulatory and nutritional activities in the human body in the form of …

miRNA dysregulation in traumatic brain injury and epilepsy: A systematic review to identify putative biomarkers for post-traumatic epilepsy

P Kumar - Metabolic Brain Disease, 2023 - Springer
Traumatic brain injury (TBI) leads to post-traumatic epilepsy (PTE); hence, both TBI and PTE
share various similar molecular mechanisms. MicroRNA (miRNA) is a small noncoding RNA …

Comparison of oncogenes, tumor suppressors, and MicroRNAs between schizophrenia and glioma: the balance of power

JS Brown Jr - Neuroscience & Biobehavioral Reviews, 2023 - Elsevier
The risk of cancer in schizophrenia has been controversial. Confounders of the issue are
cigarette smoking in schizophrenia, and antiproliferative effects of antipsychotic medications …

LINC00943 regulates miR-1252-5p/YWHAH axis to promote tumor proliferation and metastasis in lung adenocarcinoma

B Liu, H Li, J Zhou, L Wang, J Fang, Z Pu, T Xue - Heliyon, 2023 - cell.com
Lung cancer is the most common malignant tumor worldwide. In recent years, the incidence
of lung adenocarcinoma (LAD) has increased significantly, with an unfavorable 5-year …

MicroRNAs and their vital role in Apoptosis in Hepatocellular carcinoma: miRNA-based diagnostic and treatment methods

M Hajizadeh, F Hajizadeh, S Ghaffarei, MA Doustvandi… - Gene, 2023 - Elsevier
Hepatocellular carcinoma (HCC) is one of the most prevalent malignancies with high
invasive and metastatic capability. Although significant advances have been made in the …

METTL14 promotes neuroblastoma formation by inhibiting YWHAH via an m6A-YTHDF1-dependent mechanism

J Wang, H Yin, G Li, D Wu, Y Xu, Y Chen, X Wang… - Cell Death …, 2024 - nature.com
Neuroblastoma (NB) is a common childhood tumor with a high incidence worldwide. The
regulatory role of RNA N6-methyladenosine (m6A) in gene expression has attracted …