DNA methylation is of paramount importance for mammalian embryonic development. DNA
methylation has numerous functions: it is implicated in the repression of transposons and …

DNA methylation (DNAme) and histone post-translational modifications (PTMs) have
important roles in transcriptional regulation. Although many reports have characterized the …

DNA methylation at the 5-position of cytosine (5mC) plays vital roles in mammalian
development. DNA methylation is catalyzed by DNA methyltransferases (DNMTs), and the …

DNA methylation plays a critical role during development, particularly in repressing
retrotransposons. The mammalian methylation landscape is dependent on the combined …

Complex mechanisms are in place to maintain genome stability. Ubiquitination of chromatin
plays a central role in these mechanisms. The ever-growing complexity of the ubiquitin (Ub) …

Ubiquitylation is an essential posttranslational modification that controls cell division,
differentiation, and survival in all eukaryotes. By combining multiple E3 ligases (writers) …

Methylation of cytosine in CpG dinucleotides and histone lysine and arginine residues is a
chromatin modification that critically contributes to the regulation of genome integrity …

DNA methylation is a chemical modification that defines cell type and lineage through the
control of gene expression and genome stability. Disruption of DNA methylation control …

Research over the past several decades has unmasked a major contribution of disrupted
chromatin regulatory processes to human disease, particularly cancer. Advances in genome …

DNA methylation is essential to development and cellular physiology in mammals. Faulty
DNA methylation is frequently observed in human diseases like cancer and neurological …