The Mediator complex as a master regulator of transcription by RNA polymerase II
WF Richter, S Nayak, J Iwasa, DJ Taatjes - Nature Reviews Molecular …, 2022 - nature.com
The Mediator complex, which in humans is 1.4 MDa in size and includes 26 subunits,
controls many aspects of RNA polymerase II (Pol II) function. Apart from its size, a defining …
controls many aspects of RNA polymerase II (Pol II) function. Apart from its size, a defining …
Liquid–liquid phase separation in human health and diseases
Emerging evidence suggests that liquid–liquid phase separation (LLPS) represents a vital
and ubiquitous phenomenon underlying the formation of membraneless organelles in …
and ubiquitous phenomenon underlying the formation of membraneless organelles in …
Synonymous mutations in representative yeast genes are mostly strongly non-neutral
Synonymous mutations in protein-coding genes do not alter protein sequences and are thus
generally presumed to be neutral or nearly neutral,,,–. Here, to experimentally verify this …
generally presumed to be neutral or nearly neutral,,,–. Here, to experimentally verify this …
Transcription factors interact with RNA to regulate genes
O Oksuz, JE Henninger, R Warneford-Thomson… - Molecular cell, 2023 - cell.com
Transcription factors (TFs) orchestrate the gene expression programs that define each cell's
identity. The canonical TF accomplishes this with two domains, one that binds specific DNA …
identity. The canonical TF accomplishes this with two domains, one that binds specific DNA …
Characterizing cis-regulatory elements using single-cell epigenomics
Cell type-specific gene expression patterns and dynamics during development or in disease
are controlled by cis-regulatory elements (CREs), such as promoters and enhancers …
are controlled by cis-regulatory elements (CREs), such as promoters and enhancers …
RNA m6A regulates transcription via DNA demethylation and chromatin accessibility
Transcriptional regulation, which integrates chromatin accessibility, transcription factors and
epigenetic modifications, is crucial for establishing and maintaining cell identity. The …
epigenetic modifications, is crucial for establishing and maintaining cell identity. The …
Advances in targeting 'undruggable'transcription factors with small molecules
MJ Henley, AN Koehler - Nature Reviews Drug Discovery, 2021 - nature.com
Transcription factors (TFs) represent key biological players in diseases including cancer,
autoimmunity, diabetes and cardiovascular disease. However, outside nuclear receptors …
autoimmunity, diabetes and cardiovascular disease. However, outside nuclear receptors …
PLIP 2021: Expanding the scope of the protein–ligand interaction profiler to DNA and RNA
MF Adasme, KL Linnemann, SN Bolz… - Nucleic acids …, 2021 - academic.oup.com
With the growth of protein structure data, the analysis of molecular interactions between
ligands and their target molecules is gaining importance. PLIP, the protein–ligand …
ligands and their target molecules is gaining importance. PLIP, the protein–ligand …
Targeting transcription factors in cancer—from undruggable to reality
JH Bushweller - Nature Reviews Cancer, 2019 - nature.com
Mutated or dysregulated transcription factors represent a unique class of drug targets that
mediate aberrant gene expression, including blockade of differentiation and cell death gene …
mediate aberrant gene expression, including blockade of differentiation and cell death gene …
Gene–environment interactions and their impact on human health
SJ Virolainen, A VonHandorf, KCMF Viel… - Genes & …, 2023 - nature.com
The molecular processes underlying human health and disease are highly complex. Often,
genetic and environmental factors contribute to a given disease or phenotype in a non …
genetic and environmental factors contribute to a given disease or phenotype in a non …