▪ Abstract This review focuses on eukaryotic translesion synthesis (TLS) DNA polymerases,
and the emphasis is on Saccharomyces cerevisiae and human Y-family polymerases (Pols) …

Living cells are continually exposed to DNA-damaging agents that threaten their genomic
integrity. Although DNA repair processes rapidly target the damaged DNA for repair, some …

Natural DNA is exquisitely evolved to store genetic information. The chirally inverted l-DNA,
possessing the same informational capacity but resistant to biodegradation, may serve as a …

Sulfolobus solfataricus P2 DNA polymerase IV (Dpo4) is a DinB homolog that belongs to the
recently described Y-family of DNA polymerases, which are best characterized by their low …

The overwhelmingly homochiral nature of life has left a puzzle as to whether mirror-image
biological systems based on a chirally inverted version of molecular machinery could also …

Viral RNA-dependent RNA polymerases (RdRPs) play essential roles in viral genome
replication and transcription. We previously reported several structural states of the …

Cellular DNA is continually damaged by a plethora of extrinsic and intrinsic sources,
including UV light from the sun and reactive oxygen species resulting from aerobic …

DNA polymerases are molecular motors directing the synthesis of DNA from nucleotides. All
polymerases have a common architectural framework consisting of three canonical …

Human DNA polymerase η (Pol η) modulates susceptibility to skin cancer by promoting DNA
synthesis past sunlight-induced cyclobutane pyrimidine dimers that escape nucleotide …

Ultraviolet light damages DNA by catalysing covalent bond formation between adjacent
pyrimidines, generating cis–syn cyclobutane pyrimidine dimers (CPDs) as the most common …