Multiple recent studies highlight that genetic variants can have strong impacts on a
significant proportion of the human DNA methylome. Methylation quantitative trait loci, or …

The Cyclin-dependent kinase (CDK) class of serine/threonine kinases has crucial roles in
the regulation of cell cycle transition and is mainly involved in the pathogenesis of cancers …

Canonical fatty acid metabolism describes specific enzyme-substrate interactions that result
in products with well-defined chain lengths, degree (s), and positions of unsaturation. Deep …

Polyunsaturated fatty acids (PUFAs) are considered one of the most important components
of cells that influence normal development and function of many organisms, both eukaryotes …

Large-scale genome-wide association studies (GWASs) on bipolar disorder (BD) have
implicated the involvement of the fatty acid desaturase (FADS) locus. These enzymes …

Dietary polyunsaturated fatty acids (PUFAs), especially omega-3 (n-3) and n-6 long-chain
(LC) PUFAs, are indispensable for the fetus' brain supplied by the placenta. Despite being …

Eicosanoids are biologically active lipid mediators, comprising prostaglandins, leukotrienes,
thromboxanes, and lipoxins, involved in several pathophysiological processes relevant to …

Membranes are mainly composed of a lipid bilayer and proteins, constituting a checkpoint
for the entry and passage of signals and other molecules. Their composition can be …

Polyunsaturated fatty acids (PUFAs) are long chain fatty acids that are characterized by the
presence of more than one double bond. These include fatty acids such as ꞷ-3-α-linolenic …

ABSTRACT DNA methylation (DNAm) is one of the most studied epigenetic modifications.
DNAm has emerged as a key biological mechanism and biomarkers to test associations …