Proteomics plays a vital role in biomedical research in the post-genomic era. With the
technological revolution and emerging computational and statistic models, proteomic …

Alterations in DNAs could not reveal what happened in proteins. The accumulated
alterations of DNAs would change the manifestation of proteins. Therefore, as is the case in …

Both proteome and transcriptome data can help assess the relevance of non-coding somatic
mutations in cancer. Here, we combine mass spectrometry-based proteomics data with …

Post-translational modifications (PTMs) create vast structural and functional diversity of
proteins, ultimately modulating protein function and degradation, influencing cellular …

Targeted proteomics via selected reaction monitoring (SRM) or parallel reaction monitoring
(PRM) enables fast and sensitive detection of a preselected set of target peptides. However …

Parkinson's disease (PD) is a prevalent neurodegenerative disease for which robust
biomarkers are needed. Because protein structure reflects function, we tested whether …

Tumor tissue processing methodologies in combination with data‐independent acquisition
mass spectrometry (DIA‐MS) have emerged that can comprehensively analyze the …

Simple Summary The gold standard for detecting cancer and profiling tumors is tissue
biopsies. Despite this, tissue biopsies have been associated with many limitations leading to …

Continuous revision of the histologic and stage-wise classification of lung cancer by the
World Health Organization (WHO) provides the foundation for therapeutic advances by …

Breast cancer (BC) is characterized by an extensive genotypic and phenotypic
heterogeneity. In-depth investigations into the molecular bases of BC phenotypes …