Complement C3-targeted therapy in C3 glomerulopathy, a prototype of complement-mediated kidney diseases

MS Meuleman, A Grunenwald, S Chauvet - Seminars in Immunology, 2022 - Elsevier
Abstract C3 glomerulopathy (C3G) is a rare and complex kidney disease that primarily
affects young adults. Renal outcomes remain poor in the absence of specific treatment. C3G …

[HTML][HTML] Membranoproliferative glomerulonephritis recurrence after kidney transplantation: using the new classification

S Alasfar, N Carter-Monroe, AZ Rosenberg… - BMC nephrology, 2016 - Springer
Background Membranoproliferative glomerulonephritis (MPGN) is an uncommon glomerular
disorder that may lead to end stage renal disease (ESRD). With new understanding of the …

Rituximab for treatment of membranoproliferative glomerulonephritis and C3 glomerulopathies

M Rudnicki - BioMed research international, 2017 - Wiley Online Library
Membranoproliferative glomerulonephritis (MPGN) is a histological pattern of injury resulting
from predominantly subendothelial and mesangial deposition of immunoglobulins or …

Eculizumab-induced reversal of dialysis-dependent kidney failure from C3 glomerulonephritis

M Inman, G Prater, H Fatima… - Clinical Kidney …, 2015 - academic.oup.com
Abstract C3 glomerulopathy (C3G) is characterized by C3 deposits with minimal
immunoglobulin deposition caused by alternative complement pathway dysregulation …

Primary disease recurrence—effects on paediatric renal transplantation outcomes

J Bacchetta, P Cochat - Nature Reviews Nephrology, 2015 - nature.com
Primary disease recurrence after renal transplantation is mainly diagnosed by examination
of biopsy samples, but can also be associated with clinical symptoms. In some patients …

[HTML][HTML] Recurrent glomerulonephritis after renal transplantation: the clinical problem

B Infante, M Rossini, S Leo, D Troise, GS Netti… - International Journal of …, 2020 - mdpi.com
Glomerulonephritis (GN) continues to be one of the main causes of end-stage kidney
disease (ESKD) with an incidence rating from 10.5% to 38.2%. Therefore, recurrent GN …

具有肾脏意义的单克隆免疫球蛋白病诊治进展

杜静雪, 胡章学 - 肾脏病与透析肾移植杂志, 2023 - njcndt.com
与意义不明的单克隆免疫球蛋白病(MGUS) 不同, 具有肾脏意义的单克隆免疫球蛋白病(MGRS)
产生的肾毒性单克隆蛋白, 可造成肾脏等脏器的不可逆性损伤, 即使在肾移植术后也具有较高 …

[HTML][HTML] C3 glomerulopathy

HT Cook - F1000Research, 2017 - ncbi.nlm.nih.gov
C3 glomerulopathy is a recently defined entity that encompasses a group of kidney diseases
caused by abnormal control of complement activation with deposition of complement …

[HTML][HTML] Glomerular Complement Factor H–Related Protein 5 (FHR5) Is Highly Prevalent in C3 Glomerulopathy and Associated With Renal Impairment

NR Medjeral-Thomas, H Moffitt… - Kidney international …, 2019 - Elsevier
Introduction Therapeutic agents that target complement are increasingly available for
glomerular diseases. However, the mechanisms linking glomerular complement deposition …

[HTML][HTML] Complement related kidney diseases: recurrence after transplantation

M Salvadori, E Bertoni - World Journal of Transplantation, 2016 - ncbi.nlm.nih.gov
The recurrence of renal disease after renal transplantation is becoming one of the main
causes of graft loss after kidney transplantation. This principally concerns some of the …