[HTML][HTML] Deep learning in cancer diagnosis, prognosis and treatment selection

KA Tran, O Kondrashova, A Bradley, ED Williams… - Genome Medicine, 2021 - Springer
Deep learning is a subdiscipline of artificial intelligence that uses a machine learning
technique called artificial neural networks to extract patterns and make predictions from …

Transforming medical imaging with Transformers? A comparative review of key properties, current progresses, and future perspectives

J Li, J Chen, Y Tang, C Wang, BA Landman… - Medical image …, 2023 - Elsevier
Transformer, one of the latest technological advances of deep learning, has gained
prevalence in natural language processing or computer vision. Since medical imaging bear …

[HTML][HTML] Single-cell and spatial analysis reveal interaction of FAP+ fibroblasts and SPP1+ macrophages in colorectal cancer

J Qi, H Sun, Y Zhang, Z Wang, Z Xun, Z Li… - Nature …, 2022 - nature.com
Colorectal cancer (CRC) is among the most common malignancies with limited treatments
other than surgery. The tumor microenvironment (TME) profiling enables the discovery of …

TISCH2: expanded datasets and new tools for single-cell transcriptome analyses of the tumor microenvironment

Y Han, Y Wang, X Dong, D Sun, Z Liu… - Nucleic acids …, 2023 - academic.oup.com
Abstract The Tumor Immune Single Cell Hub 2 (TISCH2) is a resource of single-cell RNA-
seq (scRNA-seq) data from human and mouse tumors, which enables comprehensive …

Towards a general-purpose foundation model for computational pathology

RJ Chen, T Ding, MY Lu, DFK Williamson, G Jaume… - Nature Medicine, 2024 - nature.com
Quantitative evaluation of tissue images is crucial for computational pathology (CPath) tasks,
requiring the objective characterization of histopathological entities from whole-slide images …

GSCA: an integrated platform for gene set cancer analysis at genomic, pharmacogenomic and immunogenomic levels

CJ Liu, FF Hu, GY Xie, YR Miao, XW Li… - Briefings in …, 2023 - academic.oup.com
Cancer initiation and progression are likely caused by the dysregulation of biological
pathways. Gene set analysis (GSA) could improve the signal-to-noise ratio and identify …

[HTML][HTML] SRplot: A free online platform for data visualization and graphing

D Tang, M Chen, X Huang, G Zhang, L Zeng… - PLoS …, 2023 - journals.plos.org
Graphics are widely used to provide summarization of complex data in scientific
publications. Although there are many tools available for drawing graphics, their use is …

oncoPredict: an R package for predicting in vivo or cancer patient drug response and biomarkers from cell line screening data

D Maeser, RF Gruener, RS Huang - Briefings in bioinformatics, 2021 - academic.oup.com
Cell line drug screening datasets can be utilized for a range of different drug discovery
applications from drug biomarker discovery to building translational models of drug …

[HTML][HTML] Single-cell analyses define a continuum of cell state and composition changes in the malignant transformation of polyps to colorectal cancer

WR Becker, SA Nevins, DC Chen, R Chiu… - Nature …, 2022 - nature.com
To chart cell composition and cell state changes that occur during the transformation of
healthy colon to precancerous adenomas to colorectal cancer (CRC), we generated single …

[HTML][HTML] Evaluation of cell-free DNA approaches for multi-cancer early detection

A Jamshidi, MC Liu, EA Klein, O Venn, E Hubbell… - Cancer Cell, 2022 - cell.com
Summary In the Circulating Cell-free Genome Atlas (NCT02889978) substudy 1, we
evaluate several approaches for a circulating cell-free DNA (cfDNA)-based multi-cancer …