The molecular features that define clear cell renal cell carcinoma (ccRCC) initiation and
progression are being increasingly defined. The TRACERx Renal studies and others that …

Abstract Since the Von Hippel–Lindau (VHL) disease tumour suppressor gene VHL was
identified in 1993 as the genetic basis for a rare disorder, it has proved to be of wide medical …

Abstract The von Hippel–Lindau disease is caused by inactivating germline mutations of the
VHL tumour suppressor gene and is associated with an increased risk of a variety of …

Hypoxia‐inducible factor (HIF) plays an important role in renal tumourigenesis. In the
majority of clear cell RCC (ccRCC), the most frequent and highly vascularized RCC subtype …

Abstract von Hippel-Lindau disease, which is characterized by an increased risk of
hemangioblastomas, clear cell renal carcinomas, and pheochromocytomas, is caused by …

Von Hippel-Lindau disease (VHL) is one of the most common inherited neoplasia
syndromes and is characterized by highly vascular tumors of the eyes, brain, and spine, as …

Maintenance of oxygen homeostasis is critical for the survival of multicellular organs. As a
result, both invertebrates and vertebrates have developed highly specialized mechanisms to …

Abstract The von Hippel–Lindau tumor suppressor gene product, pVHL, functions as the
substrate recognition component of an E3-ubiquitin ligase, which targets the oxygen …

Mutation of the von Hippel–Lindau (VHL) tumor suppressor protein at codon 200 (R200W) is
associated with a disease known as Chuvash polycythemia. In addition to polycythemia …

von Hippel-Lindau (VHL) disease is a rare hereditary cancer syndrome that causes a
predisposition to renal clear-cell carcinoma, hemangioblastoma, pheochromocytoma, and …