Branching morphogenesis during development of placental villi
The placenta forms a complex interface between the mother and fetus during development
that is designed for efficient nutrient exchange. A large surface area is created by extensive …
that is designed for efficient nutrient exchange. A large surface area is created by extensive …
[HTML][HTML] von Hippel–Lindau mutation in mice recapitulates Chuvash polycythemia via hypoxia-inducible factor-2α signaling and splenic erythropoiesis
MM Hickey, JC Lam, NA Bezman… - The Journal of …, 2007 - Am Soc Clin Investig
The R200W mutation in the von Hippel–Lindau (VHL) tumor suppressor protein (pVHL) is
unique in that it is not associated with tumor development, but rather with Chuvash …
unique in that it is not associated with tumor development, but rather with Chuvash …
Regulation of vascular integrity
M Murakami, M Simons - Journal of molecular medicine, 2009 - Springer
The integrity of blood vessels is critical to vascular homeostasis. Maintenance of vascular
integrity has been conventionally regarded as a passive process that is largely dependent …
integrity has been conventionally regarded as a passive process that is largely dependent …
Essential role of endothelial Smad4 in vascular remodeling and integrity
New blood vessels are formed through the assembly or sprouting of endothelial cells (ECs)
and become stabilized by the formation of perivascular matrix and the association with …
and become stabilized by the formation of perivascular matrix and the association with …
von Hippel–Lindau disease: update on pathogenesis and systemic aspects
Purpose: To provide an update summarizing the biologic pathways governing von Hippel–
Lindau (VHL) disease pathogenesis and to provide an overview of systemic manifestations …
Lindau (VHL) disease pathogenesis and to provide an overview of systemic manifestations …
von Hippel-Lindau tumor suppressor mutants faithfully model pathological hypoxia-driven angiogenesis and vascular retinopathies in zebrafish
E van Rooijen, EE Voest, I Logister… - Disease models & …, 2010 - journals.biologists.com
Biallelic inactivation of the von Hippel-Lindau (VHL) tumor suppressor gene predisposes
human patients to the development of highly vascularized neoplasms in multiple organ …
human patients to the development of highly vascularized neoplasms in multiple organ …
Two sides to every story: the HIF‐dependent and HIF‐independent functions of pVHL
M Li, WY Kim - Journal of cellular and molecular medicine, 2011 - Wiley Online Library
von Hippel–Lindau (VHL) disease• The VHL protein, pVHL• HIF‐dependent pVHL functions‐
Hydroxylation of HIF‐HIF is a key mediator of VHL defective tumorigenesis‐HIF responsive …
Hydroxylation of HIF‐HIF is a key mediator of VHL defective tumorigenesis‐HIF responsive …
The role of VHL in the development of von Hippel-Lindau disease and erythrocytosis
P Hudler, M Urbancic - Genes, 2022 - mdpi.com
Von Hippel-Lindau disease (VHL disease or VHL syndrome) is a familial multisystem
neoplastic syndrome stemming from germline disease-associated variants of the VHL tumor …
neoplastic syndrome stemming from germline disease-associated variants of the VHL tumor …
Fetal and trophoblast PI3K p110α have distinct roles in regulating resource supply to the growing fetus in mice
J Lopez-Tello, V Pérez-García, J Khaira, LC Kusinski… - Elife, 2019 - elifesciences.org
Studies suggest that placental nutrient supply adapts according to fetal demands. However,
signaling events underlying placental adaptations remain unknown. Here we demonstrate …
signaling events underlying placental adaptations remain unknown. Here we demonstrate …
Hypoxia, HIF and the placenta
BH Fryer, MC Simon - Cell Cycle, 2006 - Taylor & Francis
Early in mammalian development the placenta, a highly vascularized organ, develops to
facilitate exchange of oxygen (O2), nutrients and waste between mother and offspring. This …
facilitate exchange of oxygen (O2), nutrients and waste between mother and offspring. This …