Renal cell cancer (RCC) is a heterogeneous disease consisting of different histologic types.
Major advances have been accomplished during the last 15 years in our understanding of …

The von Hippel–Lindau protein (pVHL) is a tumour suppressor mainly known for its role as
master regulator of hypoxia-inducible factor (HIF) activity. Functional inactivation of pVHL is …

Inactivation of the von Hippel‐Lindau (VHL) tumor suppressor has been linked to a variety of
tumors, including clear cell renal carcinoma, retinal and cerebellar hemangioblastoma, and …

Abstract The von Hippel–Lindau tumor suppressor gene (VHL) has attracted intensive
interest not only because its mutations predispose carriers to devastating tumors, but also …

Cutaneous and leptomeningeal vascular malformations are hallmarks of the Sturge-Weber
Syndrome (SWS), resulting in chronic ischemic tissue damage. The mechanisms underlying …

Decreased oxygen availability is a common feature during embryonic development as well
of malignant tumours. Hypoxia regulates many transcription factors, and one of the most …

The exposure to dioxin can compromise pregnancy outcomes and increase the risk of
preterm births. 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin (TCDD) has been demonstrated to …

The von Hippel-Lindau (VHL) syndrome is a pleomorphic familial disease characterized by
the development of highly vascularized tumors, such as hemangioblastomas of the central …

Inactivation of the von Hippel-Lindau (VHL) tumour suppressor gene is responsible for the
development of renal carcinomas, pheochromocytomas and tumours in other organs. The …

Abstract The von Hippel–Lindau (VHL) tumor suppressor gene encodes an adaptor protein
that regulates an array of transcription-dependent and-independent cellular and …