One of the leading causes for the development of adverse metabolic effects, including type 2
diabetes, dyslipidemia, and cardiovascular diseases, is the accumulation of excess body …

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two fatal
neurodegenerative diseases seen in comorbidity in up to 50% of cases. Despite tremendous …

Aberrant DNA methylation and histone modification are associated with an increased risk of
reproductive disorders such as endometriosis. However, a cause–effect relationship …

Bipolar disorder (BD) is a multifactorial illness thought to result from an interaction between
genetic susceptibility and environmental stimuli. Epigenetic mechanisms, including DNA …

Background Detecting organ and tissue damage is essential for early diagnosis, treatment
decisions, and monitoring disease progression. Methylation-based assays offer a promising …

This article reviews the literature pertinent to epigenetic changes, and in particular, DNA
methylation following traumatic brain injury (TBI). TBI is a heterogeneous disease that is a …

The present work was designed to study the mechanisms associated with Nurr1 modulation
following early life permethrin (PERM) treatment during rat's life span. Here we demonstrate …

Systemic sclerosis (SSc) is a heterogeneous and life-threatening autoimmune disease
characterized by damage to small blood vessels, interruption of immune homeostasis and …

The discovery of microRNAs (miRNAs) a little over 20 years ago was revolutionary given
that miRNAs are essential to numerous physiological and physiopathological processes …

Epigenetics refers to heritable changes in gene expression that are independent of
alterations in DNA sequence. It is now accepted that disruption of epigenetic mechanisms …