Abstract N6-methyladenosine (m6A) is the most prevalent, abundant and conserved internal
cotranscriptional modification in eukaryotic RNAs, especially within higher eukaryotic cells …

Hematopoiesis is a complex process with a variety of different signaling pathways
influencing every step of blood cell formation from the earliest precursors to final …

Runx proteins (also known as Runt-domain transcription factors) have been studied for a
long time as key regulators of cellular differentiation. RUNX2 has been described as …

The rapid advances in high‐throughput sequencing technologies have made it more evident
that epigenetic modifications orchestrate a plethora of complex biological processes. During …

In recent years, an explosion of interest for genome methylation in hematopoietic stem cells
(HSCs) differentiation and transplantation has been observed. The differentiation and timely …

The molecular pathogenesis of hematological diseases is often driven by genetic and
epigenetic alterations. Next-generation sequencing has considerably increased our …

Objective In gout, autoinflammatory responses to urate crystals promote acute arthritis flares,
but the pathogeneses of tophi, chronic synovitis, and erosion are less well understood …

Haematopoiesis in fish and mammals is a complex process, and many aspects regarding its
model and the differentiation of haematopoietic stem cells (HSCs) still remain enigmatic …

Post-translational modifications of core histones participate in controlling the expression of
genes. Methylation of lysine 4 of histone H3 (H3K4), together with acetylation of H3K27, is …

Oncogenes or tumor suppressor genes are rarely mutated in several pediatric tumors and
some early stage adult cancers. This suggests that an aberrant epigenetic reprogramming …