Mammalian genomes are punctuated by DNA sequences containing an atypically high
frequency of CpG sites termed CpG islands (CGIs). CGIs generally lack DNA methylation …

Maintaining the integrity of the gastrointestinal tract, despite the continual presence of
microbial flora and injurious agents, is essential. Epithelial continuity depends on a family of …

Genome-wide dynamic changes in DNA methylation are indispensable for germline
development and genomic imprinting in mammals. Here, we report single-base resolution …

DNA methylation is the most stable type of epigenetic modification modulating the
transcriptional plasticity of mammalian genomes. Using bisulfite DNA sequencing, we report …

Embryonic stem (ES) cells are unique in that they are pluripotent and have the ability to self-
renew. The molecular mechanisms that underlie these two fundamental properties are …

CpG islands (CGIs) are dense clusters of CpG sequences that punctuate the CpG-deficient
human genome and associate with many gene promoters. As CGIs also differ from bulk …

Despite an enormous research effort, most cases of late-onset Alzheimer's disease (LOAD)
still remain unexplained and the current biomedical science is still a long way from the …

The first cell differentiation event in mammalian embryogenesis segregates inner cell mass
lineage from the trophectoderm at the blastocyst stage. Oct-4, a member of the POU family of …

Epigenomic studies aim to define the location and nature of the genomic sequences that are
epigenetically modified. Much progress has been made towards whole-genome epigenetic …

The distribution of cytosine methylation in 6.2 Mb of the mouse genome was tested using
cohybridization of genomic representations from a methylation-sensitive restriction enzyme …