Homocysteine (Hcy) is a sulfur-containing non-proteinogenic amino acid derived in
methionine metabolism. The increased level of Hcy in plasma, hyperhomocysteinemia, is …

The biological significance of 5-methylcytosine was in doubt for many years, but is no
longer. Through targeted mutagenesis in mice it has been learnt that every protein shown by …

Introduction Folic acid is the most important dietary determinant of homocysteine (Hcy). Hcy
serves as a critical intermediate in methylation reactions. It is created from methionine and …

DNA methyltransferases catalyze the transfer of a methyl group from S‐adenosyl‐l‐
methionine to cytosine or adenine bases in DNA. These enzymes challenge the …

Dnmt3a is a de novo DNA methyltransferase that modifies unmethylated DNA. In contrast
Dnmt1 shows high preference for hemimethylated DNA. However, Dnmt1 can be activated …

Low expression of the oxidative stress sensor Keap1 is thought to be involved in
carcinogenesis. However, the mechanisms responsible for inactivation of the Keap1 gene …

Sporadic colorectal cancer (CRC) is characterized by genetic and epigenetic changes such
as regional DNA hypermethylation and global DNA hypomethylation. Epidemiological and …

If detected early, breast cancer is eminently curable. To detect breast cancer in samples with
little cellularity, a high level of sensitivity is needed. Tumor-specific promoter …

DNA methylation and histone modification promote changes in chromatin structure that may
affect gene expression in a heritable manner without directly altering the genome. As such …

Aberrant genome-wide hypomethylation has been thought to be related to tumorigenesis.
However, its mechanism and implications in hepatocellular carcinogenesis remain to be …