Alzheimer's disease (AD) is the most common form of dementia. AD brain pathology starts
decades before the onset of clinical symptoms. One early pathological hallmark is blood …

The first description of Alzheimer's disease (AD) was made in 1907 by Alois Alzheimer
(Allgemeine Zeitschrift fur Psyciatrie und Psychisch‐Gerichtliche Medizin 64, 3, 1907) …

The glucose transporter GLUT1 at the blood-brain barrier (BBB) mediates glucose transport
into the brain. Alzheimer's disease is characterized by early reductions in glucose transport …

Neurofibrillary tangles advance from layer II of the entorhinal cortex (EC-II) toward limbic and
association cortices as Alzheimer's disease evolves. However, the mechanism involved in …

Neuroinflammation is an important feature in the pathogenesis and progression of
neurodegenerative diseases such as Alzheimer´ s disease (AD), Parkinson´ s disease (PD) …

Alzheimer disease (AD) is the most common causes of neurodegenerative disorder in the
elderly individuals. Clinically, patients initially present with short-term memory loss …

Since the original description of amyloid-β plaques and tau tangles more than 100 years
ago, these lesions have been considered the neuropathological hallmarks of Alzheimer …

Protein aggregates disrupt cellular homeostasis, causing toxicity linked to
neurodegeneration. Selective autophagic elimination of aggregates is critical to protein …

Zebrafish (Danio rerio) have become a powerful tool in neuroscience research due to their
genetic tractability, molecular/physiological conservation, small body size, ease of …

Amyloid-β (Aβ) plaque deposition in specific brain regions is a pathological hallmark of
Alzheimer's disease. However, the mechanism underlying the regional vulnerability to Aβ …