Methionine uptake and metabolism is involved in a host of cellular functions including
methylation reactions, redox maintenance, polyamine synthesis and coupling to folate …

DNA methylation provides a pivotal layer of epigenetic regulation in eukaryotes that has
significant involvement for numerous biological processes in health and disease. The …

The mechanistic target of rapamycin complex 1 (mTORC1) regulates metabolism and cell
growth in response to nutrient, growth, and oncogenic signals. We found that mTORC1 …

Transcription, translation and subsequent protein modification represent the transfer of
genetic information from the archival copy of DNA to the short-lived messenger RNA, usually …

DNA methylation is an important epigenetic modification involved in many biological
processes and diseases. Recent developments in whole genome bisulfite sequencing …

Precise mapping of DNA methylation patterns in CpG islands has become essential for
understanding diverse biological processes such as the regulation of imprinted genes, X …

Purpose: Patients with high-risk myelodysplastic syndrome (MDS) have high mortality from
bone marrow failure or transformation to acute leukemia. Supportive care is standard …

The discovery of numerous hypermethylated promoters of tumour–suppressor genes, along
with a better understanding of gene–silencing mechanisms, has moved DNA methylation …

Does the inheritance of acquired characteristics play a significant role in evolution? In this
book, Eva Jablonka and Marion J. Lamb attempt to answer that question with an original …

Neoplastic cells simultaneously harbor widespread genomic hypomethylation, more
regional areas of hypermethylation, and increased DNA-methyltransferase (DNA-MTase) …